Skip to search formSkip to main contentSkip to account menu

Camptothecin

Known as: camptothecins, 21, 22-secocamptothecin-21-oic acid lactone, 20(S)-Camptothecine 
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
It is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment. In… 
Review
2006
Review
2006
  • Y. Pommier
  • Nature Reviews Cancer
  • 2006
  • Corpus ID: 25135019
Nuclear DNA topoisomerase I (TOP1) is an essential human enzyme. It is the only known target of the alkaloid camptothecin, from… 
Review
2005
Review
2005
Review
1993
Review
1993
The nuclear enzyme topoisomerase I (topo I) has been recently recognized as the target for the anticancer drug camptothecin (CPT… 
Highly Cited
1991
Highly Cited
1991
It is known that 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11), a semisynthesized derivative of… 
Highly Cited
1989
Highly Cited
1989
Camptothecin, which induces an unusual type of DNA damage by trapping cellular topoisomerase I on chromosomal DNA in the form of… 
Highly Cited
1988
Highly Cited
1988
Camptothecin, a plant alkaloid with antitumor activity, has been shown to be a potent inhibitor of nucleic acid synthesis and a… 
Highly Cited
1985
Highly Cited
1985