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Camptothecin

Known as: camptothecins, 21, 22-secocamptothecin-21-oic acid lactone, 20(S)-Camptothecine 
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
It is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment. In… Expand
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Highly Cited
2004
Highly Cited
2004
AbstractPurpose. The aim of this study was to investigate the specific changes in body distribution of camptothecin (CA) through… Expand
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Review
2000
Review
2000
Camptothecin (CPT) class of compounds has been demonstrated to be effective against a broad spectrum of tumors. Their molecular… Expand
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Highly Cited
1999
Highly Cited
1999
The objective of the present study was to investigate the specific drug targeting of anticarcinogenic drugs, such as camptothecin… Expand
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Review
1995
Review
1995
Camptothecin and taxol are secondary metabolites found, respectively, in the wood bark of Camptotheca acuminata, a native of… Expand
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Highly Cited
1992
Highly Cited
1992
Quantitative rate and equilibrium constants for the hydrolysis of the lactone (ring E) in camptothecin (1) and analogues (2-5… Expand
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Highly Cited
1991
Highly Cited
1991
It is known that 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11), a semisynthesized derivative of… Expand
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Highly Cited
1989
Highly Cited
1989
Camptothecin, which induces an unusual type of DNA damage by trapping cellular topoisomerase I on chromosomal DNA in the form of… Expand
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Highly Cited
1988
Highly Cited
1988
Camptothecin, a plant alkaloid with antitumor activity, has been shown to be a potent inhibitor of nucleic acid synthesis and a… Expand
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Highly Cited
1985
Highly Cited
1985
Camptothecin, a cytotoxic drug, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand… Expand
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