Camptothecin

Known as: camptothecins, 21, 22-secocamptothecin-21-oic acid lactone, 20(S)-Camptothecine 
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin… (More)
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
The serine/threonine protein kinase ATM signals to cell cycle and DNA repair components by phosphorylating downstream targets… (More)
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Review
2000
Review
2000
Camptothecin (CPT) class of compounds has been demonstrated to be effective against a broad spectrum of tumors. Their molecular… (More)
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Highly Cited
1999
Highly Cited
1999
UNLABELLED Replication protein A (RPA) is a DNA single-strand binding protein essential for DNA replication, recombination and… (More)
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Highly Cited
1999
Highly Cited
1999
Purpose. The aim of this study was to investigate the specific changes in body distribution of camptothecin (CA) through… (More)
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Highly Cited
1991
Highly Cited
1991
It is known that 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11), a semisynthesized derivative of… (More)
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Highly Cited
1989
Highly Cited
1989
Camptothecin, which induces an unusual type of DNA damage by trapping cellular topoisomerase I on chromosomal DNA in the form of… (More)
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Highly Cited
1989
Highly Cited
1989
Treatment of human HL-60 or KG1A leukemia cells with the topoisomerase II inhibitor etoposide resulted in extensive DNA… (More)
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Highly Cited
1989
Highly Cited
1989
Twenty-two compounds related to camptothecin, a known inhibitor of eukaryotic topoisomerase I, were studied. The following… (More)
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Highly Cited
1988
Highly Cited
1988
Camptothecin, a plant alkaloid with antitumor activity, has been shown to be a potent inhibitor of nucleic acid synthesis and a… (More)
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Highly Cited
1985
Highly Cited
1985
Camptothecin, a cytotoxic drug, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand… (More)
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