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Camptothecin

Known as: camptothecins, 21, 22-secocamptothecin-21-oic acid lactone, 20(S)-Camptothecine 
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin… 
National Institutes of Health

Related topics

Related topics

49 relations

Narrower (39)

10-hydroxycamptothecin10-methoxy-9-nitrocamptothecin11-hydroxycamptothecin12-nitrocamptothecin

Broader (2)

AlkaloidsAntineoplastic Agents, Phytogenic
Camptothecin SodiumIn BloodMureletecanNCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery.
Highly Cited
2005
Highly Cited
2005
Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo
Tumor necrosis factor related apoptosis‐inducing ligand/Apo2 ligand (TRAIL/Apo‐2L) is a novel anticancer agent, capable of… 
Highly Cited
2003
Highly Cited
2003
Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant…
Camptothecin (CPT) and its derivatives target mammalian DNA topoisomerase I (top1) and are among the most effective novel… 
Highly Cited
2002
Highly Cited
2002
Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition.
Paclitaxel (Taxol) activates a number of signal transduction pathways that lead to apoptosis. In contrast, paclitaxel also… 
Highly Cited
2001
Highly Cited
2001
DNA relaxation and cleavage assays to study topoisomerase I inhibitors.
Highly Cited
1991
Highly Cited
1991
Characterization of DNA damage induced by 3,4-estrone-o-quinone in human cells.
Highly Cited
1991
Highly Cited
1991
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
Water-soluble analogues of the antitumor alkaloid camptothecin (1) were prepared in which aminoalkyl groups were introduced into… 
Highly Cited
1990
Highly Cited
1990
Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C.
Highly Cited
1990
Highly Cited
1990
Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines.
In a previous study, we established camptothecin (CPT)-resistant cell lines, A549/CPT and HT-29/CPT, from human lung cancer A549… 
Highly Cited
1987
Highly Cited
1987
Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogues. Structure-activity correlations.
Nineteen racemic ring A substituted analogues of the antitumor agent 20(S)-camptothecin were prepared by total synthesis and… 
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