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Camptothecin

Known as: camptothecins, 21, 22-secocamptothecin-21-oic acid lactone, 20(S)-Camptothecine 
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin… 
National Institutes of Health

Related topics

Related topics

49 relations

Narrower (39)

10-hydroxycamptothecin10-methoxy-9-nitrocamptothecin11-hydroxycamptothecin12-nitrocamptothecin

Broader (2)

AlkaloidsAntineoplastic Agents, Phytogenic
Camptothecin SodiumIn BloodMureletecanNCIt Antineoplastic Agent Terminology

Papers overview

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Highly Cited
2003
Highly Cited
2003
Iodine-124 labelled annexin-V as a potential radiotracer to study apoptosis using positron emission tomography.
Highly Cited
2001
Highly Cited
2001
DNA relaxation and cleavage assays to study topoisomerase I inhibitors.
Highly Cited
2000
Highly Cited
2000
Simple and rapid determination of irinotecan and its metabolite SN-38 in plasma by high-performance liquid-chromatography: application to clinical pharmacokinetic studies.
1997
1997
DNA-topoisomerase I, a new target for the treatment of neuroblastoma.
Highly Cited
1995
Highly Cited
1995
Nucleophosmin/B23 (NPM) oligomer is a major and stable entity in HeLa cells.
Highly Cited
1994
Highly Cited
1994
Increased expression of DNA topoisomerase I gene and collateral sensitivity to camptothecin in human cisplatin-resistant bladder cancer cells.
We established three cis-diamminedichloroplatinum(II) (cisplatin)-resistant cell lines, T24/DDP5, T24/DDP7, and T24/DDP10, by the… 
Highly Cited
1991
Highly Cited
1991
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
Water-soluble analogues of the antitumor alkaloid camptothecin (1) were prepared in which aminoalkyl groups were introduced into… 
Highly Cited
1990
Highly Cited
1990
Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines.
In a previous study, we established camptothecin (CPT)-resistant cell lines, A549/CPT and HT-29/CPT, from human lung cancer A549… 
Highly Cited
1987
Highly Cited
1987
Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogues. Structure-activity correlations.
Nineteen racemic ring A substituted analogues of the antitumor agent 20(S)-camptothecin were prepared by total synthesis and… 
Highly Cited
1972
Highly Cited
1972
Selective interruption of high molecular weight RNA synthesis in HeLa cells by camptothecin.
THE study of macromolecular metabolism in eukaryotic cells has depended to a large extent on the use of selective inhibitors… 
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