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Camptothecin Sodium

Known as: Camptothecin Sodium Salt, Camptothecin, sodium salt, Sodium camptothecin 
The sodium salt of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase… 
National Institutes of Health

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Related topics

2 relations
CamptothecinNCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38.
Highly Cited
2000
Highly Cited
2000
Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2.
7-Ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin (irinotecan; CPT-11) is a prodrug activated by… 
Highly Cited
2000
Highly Cited
2000
Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans.
7-Ethyl-10[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin (CPT-11), a DNA topoisomerase I inhibitor, undergoes several… 
Review
1997
Review
1997
Clinical Pharmacokinetics of Irinotecan
SummaryThis article reviews the clinical pharmacokinetics of a water-soluble analogue of camptothecin, irinotecan {CPT-11 or 7… 
Highly Cited
1996
Highly Cited
1996
Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity
Camptothecin is an S-phase-specific anticancer agent that inhibits the activity of the enzyme DNA topoisomerase-I (topo-I… 
Highly Cited
1994
Highly Cited
1994
Differential interactions of camptothecin lactone and carboxylate forms with human blood components.
The intrinsic fluorescent emissions from the lactone and carboxylate forms of camptothecin have been exploited in order to… 
Highly Cited
1993
Highly Cited
1993
Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system.
The extreme S-phase-specific cytotoxicity of camptothecin has been shown to involve active DNA replication. To investigate the… 
Highly Cited
1992
Highly Cited
1992
Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue.
Topotecan (TPT, 9-dimethylaminomethyl-10-hydroxycamptothecin) is the first topoisomerase I-directed cytotoxic agent to enter… 
Highly Cited
1989
Highly Cited
1989
Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin.
Yeast Saccharomyces cerevisiae strains that are permeable to the antitumor alkaloid camptothecin are killed by the drug if they… 
Highly Cited
1984
Highly Cited
1984
Physical change in cytoplasmic messenger ribonucleoproteins in cells treated with inhibitors of mRNA transcription
Exposure of intact cells to UV light brings about cross-linking of polyadenylated mRNA to a set of cytoplasmic proteins which are… 
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