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Camptothecin Sodium

Known as: Camptothecin Sodium Salt, Camptothecin, sodium salt, Sodium camptothecin 
The sodium salt of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase… 
National Institutes of Health

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2 relations
CamptothecinNCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Structure and properties of camptothecin derivatives, their protonated forms, and model interaction with the topoisomerase I-DNA complex.
The structure and properties of the 11 Camptothecin derivatives (CPTs) and their different mono-, di-, and triprotonated forms… 
2004
2004
Synthesis of a macromolecular camptothecin conjugate with dual phase drug release.
A water soluble macromolecular conjugate of camptothecin (CPT) with a new, dual phase hydrolytic drug release mechanism was… 
2003
2003
Phase I pharmacological and bioavailability study of oral diflomotecan (BN80915), a novel E-ring-modified camptothecin analogue in adults with solid tumors.
PURPOSE Diflomotecan (BN80915) is an E-ring modified camptothecin analogue that possesses greater lactone stability in plasma… 
2002
2002
Stable Supersaturated Aqueous Solutions of Silatecan 7-t-Butyldimethylsilyl-10-Hydroxycamptothecin via Chemical Conversion in the Presence of a Chemically Modified β-Cyclodextrin
AbstractPurpose. A method for obtaining clear supersaturated aqueous solutions for parenteral administration of the poorly… 
2002
2002
Multicentre phase II and pharmacokinetic study of RFS2000 (9-nitro-camptothecin) administered orally 5 days a week in patients with glioblastoma multiforme.
2001
2001
Why drugs fail: of mice and men revisited.
Of the large number of promising anticancer agents entering into clinical testing, only a disappointingly small number ultimately… 
2001
2001
Sequence-specific trapping of topoisomerase I by DNA binding polyamide-camptothecin conjugates.
Hairpin pyrrole-imidazole polyamides are synthetic ligands that bind in the minor groove of DNA with affinities and specificities… 
Highly Cited
1997
Highly Cited
1997
Effect of CPT-11 in combination with other anticancer agents in lung cancer cells
To determine the optimal combination of commonly used anticancer agents with 7-ethyl-10-hydroxy-camptothecin (SN-38), an active… 
1995
1995
Antitumor activities of a new indolocarbazole substance, NB-506, and establishment of NB-506-resistant cell lines, SBC-3/NB.
The novel anticancer glucosyl derivative of indolo-carbazole (NB-506), an inhibitor of DNA topoisomerase I, exhibited strong in… 
Highly Cited
1986
Highly Cited
1986
Photosensitive DNA cleavage and phage inactivation by copper(II)-camptothecin.
Upon irradiation with 365-nm light, copper(II)-camptothecin significantly produced single- and double-strand breaks of DNA and… 
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