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Camptothecin Sodium

Known as: Camptothecin Sodium Salt, Camptothecin, sodium salt, Sodium camptothecin 
The sodium salt of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase… 
National Institutes of Health

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CamptothecinNCIt Antineoplastic Agent Terminology

Papers overview

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Highly Cited
2007
Highly Cited
2007
Soluble camptothecin derivatives prepared by click cycloaddition chemistry on functional aliphatic polyesters.
Aliphatic polyesters are of interest as biomaterials and drug-delivery vehicles, as their ability to degrade under physiological… 
Highly Cited
2004
Highly Cited
2004
Polymer Delivery of Camptothecin against 9L Gliosarcoma: Release, Distribution, and Efficacy
Camptothecin is a potent antineoplastic agent that has shown efficacy against multiple tumor lines in vitro; unfortunately… 
2003
2003
Camptothecin poly[n-(2-hydroxypropyl) methacrylamide] copolymers in antitopoisomerase-I tumor therapy: intratumor release and antitumor efficacy.
Soluble copolymers of camptothecin (CPT), based on poly[N-(2-hydroxypropyl) methacrylamide] (pHPMA), were obtained by conjugation… 
Highly Cited
2001
Highly Cited
2001
Potent antitumor activity and improved pharmacological profile of ST1481, a novel 7-substituted camptothecin.
Relevant drawbacks of the molecular structure and mechanism of the action of camptothecins are the instability of the E ring… 
Highly Cited
2000
Highly Cited
2000
New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer
BNP1350, 7‐[(2‐trimethylsilyl)ethyl]‐20(S)‐camptothecin, is a novel semi‐synthetic, highly lipophilic, silicon‐containing… 
Highly Cited
1997
Highly Cited
1997
Effect of CPT-11 in combination with other anticancer agents in lung cancer cells
To determine the optimal combination of commonly used anticancer agents with 7-ethyl-10-hydroxy-camptothecin (SN-38), an active… 
Review
1995
Review
1995
Preclinical studies of water-insoluble camptothecin congeners: cytotoxicity, development of resistance, and combination treatments.
Water-insoluble camptothecin (CPT) congeners are rapidly establishing themselves as promising anticancer drugs. In vitro, they… 
1995
1995
Antitumor activities of a new indolocarbazole substance, NB-506, and establishment of NB-506-resistant cell lines, SBC-3/NB.
The novel anticancer glucosyl derivative of indolo-carbazole (NB-506), an inhibitor of DNA topoisomerase I, exhibited strong in… 
Highly Cited
1993
Highly Cited
1993
Cellular and chromosomal hypersensitivity to DNA crosslinking agents and topoisomerase inhibitors in the radiosensitive Chinese hamster irs mutants: phenotypic similarities to ataxia telangiectasia…
The mutants irs1, irs2 and irs3 were previously isolated from the Chinese hamster line V79-4 on the basis of their… 
Highly Cited
1993
Highly Cited
1993
Efficacy of camptothecin congeners in the treatment of human breast carcinoma xenografts.
We have shown recently that the plant alkaloid camptothecin and some of its derivatives inhibit growth of human breast carcinoma… 
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