7-ethyl-10-hydroxycamptothecin

Known as: 7-Ethyl-10-hydroxy-20(S)-camptothecin 
 
National Institutes of Health

Papers overview

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2006
2006
Polymorphisms in UGT1A9 were associated with reduced toxicity and increased response to irinotecan in cancer patients. UDP… (More)
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Highly Cited
2004
Highly Cited
2004
Irinotecan hydrochloride (CPT-11) is a potent anticancer drug that is converted to its active metabolite, 7-ethyl-10… (More)
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2004
2004
One activity potentially limiting the efficacy of camptothecin anticancer agents is their cellular efflux by the ATP-binding… (More)
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Highly Cited
2003
Highly Cited
2003
In vitro metabolic studies revealed that along with UDP-glucuronosyltransferase (UGT) 1A1, the hepatic UGT1A9 and the… (More)
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Highly Cited
2002
Highly Cited
2002
7-Ethyl-10-hydroxycamptothecin (SN-38) is the pharmacologically active metabolite of irinotecan, in addition to being responsible… (More)
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Highly Cited
2001
Highly Cited
2001
Overexpression of breast cancer resistance protein (BCRP) ABCG2 reportedly confers cancer cell resistance to camptothecin-based… (More)
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Highly Cited
2001
Highly Cited
2001
1. The human liver UDP-glucuronosyltransferase (UGT) isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin… (More)
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Highly Cited
2001
Highly Cited
2001
Because the activities of HER family members are elevated and/or aberrant in a variety of human neoplasms, these cell surface… (More)
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1999
1999
7-Ethyl-10-hydroxycamptothecin (SN-38) is a very promising anticancer drug used for the treatment of metastatic colonrectal… (More)
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Highly Cited
1994
Highly Cited
1994
We measured the plasma concentrations of 7-ethyl-10-[4-(1-piperidino)-1- piperidine]carbonyloxycamptothecin (CPT-11) and the… (More)
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