gamma-Secretase

Known as: Gamma Secretase 
A protein complex that plays a role in the intramembrane cleavage of integral proteins such as Notch receptors and amyloid beta A4 protein.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
010020019942018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
gamma-secretase catalyzes the intramembrane cleavage of amyloid precursor protein (APP) and Notch after their extracellular… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and gamma-secretase to release amyloid peptides… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
gamma-Secretase is a membrane protein complex with an unusual aspartyl protease activity that catalyses the regulated… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Mutations in presenilin genes account for the majority of the cases of the familial form of Alzheimer's disease (FAD). Presenilin… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Presenilins are components of the gamma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Inhibition of amyloid beta-peptide (Abeta) production by blocking gamma-secretase activity is at present one of the most… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
ErbB-4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding of its… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Converging lines of evidence implicate the beta-amyloid peptide (Ass) as causative in Alzheimer's disease. We describe a novel… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Gamma-secretase-like proteolysis at site 3 (S3), within the transmembrane domain, releases the Notch intracellular domain (NICD… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation… (More)
Is this relevant?