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gamma-Secretase

Known as: Gamma Secretase 
A protein complex that plays a role in the intramembrane cleavage of integral proteins such as Notch receptors and amyloid beta A4 protein.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The amyloid precursor protein (APP) undergoes constitutive shedding by a protease activity called alpha-secretase. This is… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE To evaluate the safety, tolerability, and amyloid beta (Abeta) response to the gamma-secretase inhibitor LY450139 in… Expand
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Highly Cited
2007
Highly Cited
2007
γ-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy for… Expand
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Highly Cited
2007
Highly Cited
2007
Notch receptors are key regulators of development by controlling cell-fate determination in many multicellular organisms. Genes… Expand
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Highly Cited
2003
Highly Cited
2003
γ-Secretase catalyzes the intramembrane proteolysis of Notch, β-amyloid precursor protein, and other substrates as part of a new… Expand
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Highly Cited
2003
Highly Cited
2003
gamma-Secretase is a membrane protein complex with an unusual aspartyl protease activity that catalyses the regulated… Expand
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Highly Cited
2001
Highly Cited
2001
ErbB-4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding of its… Expand
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Highly Cited
2000
Highly Cited
2000
Converging lines of evidence implicate the beta-amyloid peptide (Ass) as causative in Alzheimer's disease. We describe a novel… Expand
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Highly Cited
2000
Highly Cited
2000
Gamma-secretase-like proteolysis at site 3 (S3), within the transmembrane domain, releases the Notch intracellular domain (NICD… Expand
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Highly Cited
1999
Highly Cited
1999
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation… Expand
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