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gamma-Secretase

Known as: Gamma Secretase 
A protein complex that plays a role in the intramembrane cleavage of integral proteins such as Notch receptors and amyloid beta A4 protein.
National Institutes of Health

Related topics

Related topics

10 relations
ERBB4 Signaling PathwayGamma-Secretase Mediated ErbB4 Signaling PathwayGamma-Secretase Subunit PEN-2Presenilin-1

Broader (2)

Endopeptidasessecretase

Papers overview

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Highly Cited
2010
Highly Cited
2010
Acute γ-Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid-β Production to Alternative APP Fragments without Amyloid-β Rebound
The accumulation of amyloid β (Aβ) in Alzheimer's disease is caused by an imbalance of production and clearance, which leads to… 
Highly Cited
2006
Highly Cited
2006
Mapping of notch activation during cochlear development in mice: Implications for determination of prosensory domain and cell fate diversification
Recent chick experiments have shown that Notch signaling plays context‐dependent distinct roles in inner ear development… 
Highly Cited
2005
Highly Cited
2005
γ-Secretase Substrate Selectivity Can Be Modulated Directly via Interaction with a Nucleotide-binding Site*
γ-Secretase is an unusual protease with an intramembrane catalytic site that cleaves many type I membrane proteins, including the… 
Highly Cited
2003
Highly Cited
2003
Gamma-secretase activity is present in rafts but is not cholesterol-dependent.
Cholesterol has been claimed to be involved in the generation and/or accumulation of amyloid beta protein (Abeta). However, the… 
Highly Cited
2003
Highly Cited
2003
Notch1 Competes with the Amyloid Precursor Protein for γ-Secretase and Down-regulates Presenilin-1 Gene Expression*
Presenilin 1 (PS1) is a critical component of theγ-secretase complex, which is involved in the cleavage of several substrates… 
Highly Cited
2003
Highly Cited
2003
Proteasome‐mediated degradation of the C‐terminus of the Alzheimer's disease β‐amyloid protein precursor: Effect of C‐terminal truncation on production of β‐amyloid protein
The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein precursor (APP). Cleavage of APP by… 
Highly Cited
2001
Highly Cited
2001
Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides.
Recent studies of gamma-secretase have pointed out that it may be comprised of a multisubunit complex with presenilin 1 and… 
Highly Cited
2000
Highly Cited
2000
The use of Seldi ProteinChip™ Arrays to monitor production of Alzheimer's β‐amyloid in transfected cells
β‐Amyloid (Aβ), a 39‐43 residue peptide, is the principal component of senile plaques found in the brains of patients with… 
Highly Cited
2000
Highly Cited
2000
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
The beta-amyloid precursor protein (beta-APP), which is involved in the pathogenesis of Alzheimer's disease, and the Notch… 
Highly Cited
1997
Highly Cited
1997
Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases.
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