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gamma-Secretase

Known as: Gamma Secretase 
A protein complex that plays a role in the intramembrane cleavage of integral proteins such as Notch receptors and amyloid beta A4 protein.
National Institutes of Health

Related topics

Related topics

10 relations
ERBB4 Signaling PathwayGamma-Secretase Mediated ErbB4 Signaling PathwayGamma-Secretase Subunit PEN-2Presenilin-1

Broader (2)

Endopeptidasessecretase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors.
PURPOSE Aberrant Notch signaling has been implicated in the pathogenesis of many human cancers. MK-0752 is a potent, oral… 
Highly Cited
2007
Highly Cited
2007
The Inhalation Anesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Amyloid β-Protein Accumulation
The anesthetic isoflurane has been reported to induce apoptosis and increase Aβ generation and aggregation. However, the… 
Highly Cited
2005
Highly Cited
2005
The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate*
BACE is a transmembrane protease with β-secretase activity that cleaves the amyloid precursor protein (APP). After BACE cleavage… 
Review
2004
Review
2004
Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.
In 1959, Dave Brubeck and Paul Desmond revolutionized modern jazz music by composing their unforgettable Take Five in 5/4, one of… 
Highly Cited
2004
Highly Cited
2004
Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis*
Increasing evidence suggests an important role of mitochondrial dysfunction in the pathogenesis of Alzheimer's disease. Thus, we… 
Highly Cited
2004
Highly Cited
2004
Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease.
Highly Cited
2003
Highly Cited
2003
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
γ-Secretase catalyzes the intramembrane proteolysis of Notch, β-amyloid precursor protein, and other substrates as part of a new… 
Highly Cited
2000
Highly Cited
2000
Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain
Converging lines of evidence implicate the beta‐amyloid peptide (Aβ) as causative in Alzheimer's disease. We describe a novel… 
Highly Cited
2000
Highly Cited
2000
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.
gamma-Secretase is a membrane-associated protease that cleaves within the transmembrane region of amyloid precursor protein to… 
Highly Cited
1997
Highly Cited
1997
Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins*
Mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes cause the most common and aggressive form of early onset… 
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