Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.
[Mammalian neural stem cells].
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury
It is suggested that Stat3 is a key regulator of reactive astrocytes in the healing process after SCI, providing a potential target for intervention in the treatment of CNS injury.
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow
This study used phenotypic, morphological, and functional criteria to identify and prospectively isolate a subset of MSCs (PDGFRα+Sca-1+CD45−TER119−) from adult mouse bone marrow and provided the useful method needed to identify M SCs as defined in vivo entities.
Asymmetric Inheritance of Radial Glial Fibers by Cortical Neurons
The Neural RNA-Binding Protein Musashi1 Translationally Regulates Mammalian numb Gene Expression by Interacting with Its mRNA
The results suggested that Msi1 could regulate the expression of its target gene at the translational level, and it was found that Notch signaling activity was increased byMsi1 expression in connection with the posttranscriptional down-regulation of them-numb gene.
Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum
Evidence is reported that, after a stroke, subventricular zone GFAP-expressing cells are capable of producing new neurons outside the olfactory bulbs, and long-term tracing of the green fluorescent-labeled cells revealed that the SVZ-derived neuroblasts differentiated into mature neurons in the striatum, in which they expressed neuronal-specific nuclear protein and formed synapses with neighboring striatal cells.
Molecular Identity of Periglomerular and Short Axon Cells
It is shown that different JG cell chemotypes contribute to distinct microcircuits within or between glomeruli, and their interglomerular connections argue that they are more appropriately classified as SA cells.
Musashi1: An Evolutionally Conserved Marker for CNS Progenitor Cells Including Neural Stem Cells
Musashi1 was localized to the perikarya of CNS stem-like cells and non-oligodendroglial progenitor cells without shifting to cell processes or endfeet, and is therefore advantageous for identifying each cell and counting cells in situ.
New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain
It is shown that neuroblast migration parallels cerebrospinal fluid (CSF) flow, and results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.