H. Okano

Publications1,388
h-index122
Citations60,443
Highly Influential Citations2,835
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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
TLDR
The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration. Expand
[Mammalian neural stem cells].
  • T. Shimazaki, H. Okano
  • Medicine, Biology
  • Tanpakushitsu kakusan koso. Protein, nucleic acid…
  • 1 March 2008
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow
TLDR
This study used phenotypic, morphological, and functional criteria to identify and prospectively isolate a subset of MSCs (PDGFRα+Sca-1+CD45−TER119−) from adult mouse bone marrow and provided the useful method needed to identify M SCs as defined in vivo entities. Expand
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury
TLDR
It is suggested that Stat3 is a key regulator of reactive astrocytes in the healing process after SCI, providing a potential target for intervention in the treatment of CNS injury. Expand
Asymmetric Inheritance of Radial Glial Fibers by Cortical Neurons
TLDR
This work intensively monitored divisions of RGCs in DiI-labeled slices from the embryonic day 14 mouse cortex and revealed the fate of radial glial processes, which lead to ascent of the neuron by using the "recycled" radial fiber. Expand
The Neural RNA-Binding Protein Musashi1 Translationally Regulates Mammalian numb Gene Expression by Interacting with Its mRNA
TLDR
The results suggested that Msi1 could regulate the expression of its target gene at the translational level, and it was found that Notch signaling activity was increased byMsi1 expression in connection with the posttranscriptional down-regulation of them-numb gene. Expand
Molecular Identity of Periglomerular and Short Axon Cells
TLDR
It is shown that different JG cell chemotypes contribute to distinct microcircuits within or between glomeruli, and their interglomerular connections argue that they are more appropriately classified as SA cells. Expand
Musashi1: An Evolutionally Conserved Marker for CNS Progenitor Cells Including Neural Stem Cells
TLDR
Musashi1 was localized to the perikarya of CNS stem-like cells and non-oligodendroglial progenitor cells without shifting to cell processes or endfeet, and is therefore advantageous for identifying each cell and counting cells in situ. Expand
Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum
TLDR
Evidence is reported that, after a stroke, subventricular zone GFAP-expressing cells are capable of producing new neurons outside the olfactory bulbs, and long-term tracing of the green fluorescent-labeled cells revealed that the SVZ-derived neuroblasts differentiated into mature neurons in the striatum, in which they expressed neuronal-specific nuclear protein and formed synapses with neighboring striatal cells. Expand
repo encodes a glial-specific homeo domain protein required in the Drosophila nervous system.
TLDR
The repo gene encoded a homeo domain protein suggesting that it might be a transcriptional regulator of genes required for glial development, and Expression of repo appeared to be specific to glia throughout development. Expand
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