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Presenilin-1

Known as: Presenilin 1, EC 3.4.23.-, Presenilin-1 [Chemical/Ingredient] 
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes… 
National Institutes of Health

Related topics

Related topics

28 relations
Alzheimer's DiseaseAlzheimer's Disease Pathway KEGGAspartic Acid ProteasesEnzyme Gene

Papers overview

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Highly Cited
2011
Highly Cited
2011
Epigenetic mechanisms of amyloid-β production in anisomycin-treated SH-SY5Y cells
Highly Cited
2008
Highly Cited
2008
Effects of progesterone administration and APPswe+PSEN1Δe9 mutation for cognitive performance of mid-aged mice
Review
2005
Review
2005
Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease
Several lines of evidence indicate that the Aβ peptide is involved at some level in the pathological process that results in the… 
Highly Cited
2001
Highly Cited
2001
Presenilin-1–associated abnormalities in regional cerebral perfusion
Objective: To investigate the influence of the presenilin-1 gene (PS-1) mutation on regional cerebral perfusion, SPECT was… 
Highly Cited
2000
Highly Cited
2000
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
The beta-amyloid precursor protein (beta-APP), which is involved in the pathogenesis of Alzheimer's disease, and the Notch… 
Highly Cited
1999
Highly Cited
1999
Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.
Most familial early-onset Alzheimer's disease cases are caused by mutations in the presenilin 1 (PS1) gene. Subcellular… 
Highly Cited
1999
Highly Cited
1999
Induction of presenilins in the rat brain after middle cerebral arterial occlusion
1999
1999
Dual Roles of Proteasome in the Metabolism of Presenilin 1
Abstract : Presenilin 1 (PS1) has been identified as a causative gene for most early‐onset familial Alzheimer's disease… 
Highly Cited
1997
Highly Cited
1997
Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Pathogenic mutations in presenilin 1 (PS1) are associated with approximately 50% of early-onset familial Alzheimer disease. PS1… 
Highly Cited
1997
Highly Cited
1997
Developmental Regulation of Presenilin-1 Processing in the Brain Suggests a Role in Neuronal Differentiation*
Most cases of early-onset familial Alzheimer’s disease are caused by mutations in the presenilin genes. Presenilin-1 (PS1) is… 
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