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Presenilin-1
Known as:
Presenilin 1
, EC 3.4.23.-
, Presenilin-1 [Chemical/Ingredient]
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Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes…
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National Institutes of Health
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Related topics
Related topics
28 relations
Alzheimer's Disease
Alzheimer's Disease Pathway KEGG
Aspartic Acid Proteases
Enzyme Gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
IN-SILICO SCRUTINY AND MOLECULAR DOCKING ANALYSIS FOR BETA SECRETASE-1 AND PRESENILIN-1
S. Chandra
,
Sapna Khowal
,
S. Wajid
2014
Corpus ID: 85438102
We have performed comparative scrutiny between the canonical and non-canonical isoforms of beta secretase-1 and presenilin-1 by…
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2014
2014
Unusual catalytic activity of iron containing mesoporous materials for synthesis of diphenylmethane
Raveendranath Reddy Kanchamreddy
,
Suresh Mutyala
,
M. Kantam
,
P. Srinivasu
2014
Corpus ID: 9846812
Mesoporous ferrosilicates with various Si/Fe mole ratios have been prepared for the Friedel-Crafts alkylation reaction to…
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2004
2004
Abnormal fluid-attenuated inversion recovery signal foci in the splenium of a patient with presenilin-1 mutation.
J. Adair
,
Roland R. Lee
AJNR. American journal of neuroradiology
2004
Corpus ID: 35573181
A recent article associated discrete regions of abnormal T2 prolongation in the splenium of the corpus callosum with aging and…
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2004
2004
Effects of presenilins and beta-amyloid precursor protein on delayed rectifier potassium channels in cultured rat hippocampal neurons.
Wei Zhang
,
Hong-wei Jin
,
Xiao-Liang Wang
Acta Pharmacologica Sinica
2004
Corpus ID: 41284219
AIM To study the effects of presenilin-1 (PS-1), presenilin-2 (PS-2), and amyloid beta-protein precursor (APP695) on delayed…
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2003
2003
A Novel Mutation in the PSEN 2 Gene ( T 430 M ) Associated With Variable Expression in a Family With Early-Onset Alzheimer Disease
M. Ezquerra
,
A. Lleó
,
+6 authors
R. Oliva
2003
Corpus ID: 27397215
Patients and Methods: The proband was a 49-yearold individual who displayed progressive dementia beginning at age 45 years. One…
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2003
2003
Quantum computing: Logic gateway
A. Steane
Nature
2003
Corpus ID: 4422013
Two groups have created logic gates using pairs of trapped ions. As components of a quantum computer, these gates have the…
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2003
2003
High sensitive detection of presenilin-1 point mutation based on electrochemiluminescence
De-Bin Zhu
,
XlNGDa
,
Xing-Yan Shen
,
Gui-Hong Yan
2003
Corpus ID: 100607720
Electrochemiluminescence (ECL) is a high- sensitive detection method with broad biological applications. Ruthenium (Ⅱ) tris…
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2003
2003
Gene mutation of presenilin-1 in Chinese familial Alzheimer’s disease
Jia Jian
2003
Corpus ID: 88431445
Objective To investigate the role of the gene mutation of presenilin 1(PS 1) in familial Alzheimer disease (FAD) Methods Three…
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2002
2002
2 1 2 1 C a Stores and capacitative Ca entry in human neuroblastoma ( SH-SY 5 Y ) cells expressing a familial Alzheimer ’ s disease presenilin-1 mutation
I. Smith
,
J. Boyle
,
P. F. Vaughan
,
H. Pearson
,
R. Cowburn
,
C. Peers
2002
Corpus ID: 13059768
21 Presenilins are involved in the proteolytic production of Alzheimer’s amyloid peptides, but are also known to regulate Ca 21…
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1996
1996
Presenilin-1 polymorphism and Alzheimer's disease.
C. Bouras
,
P. Giannakopoulos
,
J. Schioi
,
N. Tezapsidis
,
N. Robakis
The Lancet
1996
Corpus ID: 35060193