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Adult Bone Marrow Stromal Cells Differentiate into Neural Cells in Vitro
It is demonstrated that human and mouse BMSC can be induced to differentiate into neural cells under experimental cell culture conditions.
Intravenous Administration of Human Umbilical Cord Blood Reduces Behavioral Deficits After Stroke in Rats
Intravenously administered HUCBC enter brain, survive, migrate, and improve functional recovery after stroke in rats, and may provide a cell source to treat stroke.
Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors.
Findings suggest the existence of a brain cholinergic pathway that regulates microglial activation through alpha 7 nicotinic receptors in the brain, and may also represent additional mechanism underlying nicotine's reported neuroprotective properties.
Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes.
- R. Papke, P. Sanberg, R. Shytle
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 May 2001
It is suggested that in chronic (i.e., therapeutic) application, S-(+)-mecamylamine might be preferable to R-(-)-micylamine in terms of equilibrium inactivation of neuronal receptors with decreased side effects associated with muscle-type receptors.
The catalepsy test: its ups and downs.
The present article reviews the wide variety of parameters chosen by investigators that measure catalepsy, and it is argued that a universal, standardized bar test be adopted by researchers.
Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease.
Grafts of fetal mesencephalic tissue can survive for a long period in the human brain and restore dopaminergic innervation to the striatum in patients with Parkinson's disease.
Nicotinic acetylcholine receptors as targets for antidepressants
- R. Shytle, A. Silver, R. Lukas, M. Newman, D. Sheehan, P. Sanberg
- Psychology, BiologyMolecular Psychiatry
- 24 July 2002
Preliminary evidence is presented suggesting that the potent, centrally acting nAChR antagonist, mecamylamine, which is devoid of monoamine reuptake inhibition, may reduce symptoms of depression and mood instability in patients with comorbid depression and bipolar disorder.
Infusion of Human Umbilical Cord Blood Cells in a Rat Model of Stroke Dose-Dependently Rescues Behavioral Deficits and Reduces Infarct Volume
Previous observations of H UCBC infusion in the MCAO rat stroke model are extended by demonstrating a dose relationship between HUCBC, behavioral improvement, and neuronal sparing.
Central Nervous System Entry of Peripherally Injected Umbilical Cord Blood Cells Is Not Required for Neuroprotection in Stroke
The data show that central nervous system availability of grafted cells is not a prerequisite for acute neuroprotection provided that therapeutic molecules secreted by these cells could cross the BBB.