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Adult Bone Marrow Stromal Cells Differentiate into Neural Cells in Vitro
- J. Sanchez-Ramos, S. Song, F. Cardozo-Pelaez, C. Hazzi, P. Sanberg
- Biology, Medicine
- Experimental Neurology
- 1 August 2000
Bone marrow stromal cells (BMSC) normally give rise to bone, cartilage, and mesenchymal cells. Recently, bone marrow cells have been shown to have the capacity to differentiate into myocytes,… Expand
Intravenous Administration of Human Umbilical Cord Blood Reduces Behavioral Deficits After Stroke in Rats
Background and Purpose— Human umbilical cord blood cells (HUCBC) are rich in stem and progenitor cells. In this study we tested whether intravenously infused HUCBC enter brain, survive,… Expand
Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors.
Almost all degenerative diseases of the CNS are associated with chronic inflammation. A central step in this process is the activation of brain mononuclear phagocyte cells, called microglia. While it… Expand
The catalepsy test: its ups and downs.
The typical catalepsy test consists of placing an animal into an unusual posture and recording the time taken to correct this posture. This time is regarded as an index of the intensity of catalepsy.… Expand
Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes.
- R. Papke, P. Sanberg, R. Shytle
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 May 2001
Because mecamylamine, a nicotinic receptor antagonist, is used so often in nicotine research and because mecamylamine may have important therapeutic properties clinically, it is important to fully… Expand
Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease.
- J. Kordower, T. Freeman, +7 authors D. Perl
- Medicine, Materials Science
- The New England journal of medicine
- 27 April 1995
BACKGROUND Trials are under way to determine whether fetal nigral grafts can improve motor function in patients with Parkinson's disease. Some studies use fluorodopa uptake on positron-emission… Expand
Nicotinic acetylcholine receptors as targets for antidepressants
- R. Shytle, A. Silver, R. Lukas, M. Newman, D. Sheehan, P. Sanberg
- Psychology, Medicine
- Molecular Psychiatry
- 24 July 2002
While the monoamine deficiency hypothesis of depression is still most commonly used to explain the actions of antidepressant drugs, a growing body of evidence has accumulated that is not adequately… Expand
Infusion of Human Umbilical Cord Blood Cells in a Rat Model of Stroke Dose-Dependently Rescues Behavioral Deficits and Reduces Infarct Volume
Background and Purpose— Intravenously delivered human umbilical cord blood cells (HUCBC) have been previously shown to improve functional recovery of stroked rats. To extend these findings, we… Expand
Timing of Cord Blood Treatment after Experimental Stroke Determines Therapeutic Efficacy
- J. Newcomb, C. T. Ajmo, C. Sanberg, P. Sanberg, K. Pennypacker, A. Willing
- Cell transplantation
- 1 March 2006
Embolic stroke is thought to cause irreparable damage in the brain immediately adjacent to the region of reduced blood perfusion. Therefore, much of the current research focuses on treatments such as… Expand
Central Nervous System Entry of Peripherally Injected Umbilical Cord Blood Cells Is Not Required for Neuroprotection in Stroke
Background and Purpose— To date, stem cell graft-mediated neuroprotection is equated with graft survival and secretion of neurotrophic factors in the brain. Here, we examined whether neuroprotection… Expand