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Aspartic Acid Proteases

Known as: Aspartic Acid Proteinases, Aspartic Proteinases, Aspartic Acid Proteases [Chemical/Ingredient] 
Aspartyl Proteases (Aspartic Endopeptidases) have an acidic residue (aspartate) involved in the catalytic process, have a pH optimum below 5 and… 
National Institutes of Health

Related topics

Related topics

19 relations
Aspartic Acid EndopeptidasesBACE1 protein, humanBeta-Secretase 2, humanCATHEPSIN D

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1997
Highly Cited
1997
Increased Expression of Cathepsins E and D in Neurons of the Aged Rat Brain and Their Colocalization with Lipofuscin and Carboxy‐Terminal Fragments of Alzheimer Amyloid Precursor Protein
Abstract: Age‐related changes in the expression and localization of two distinct intracellular aspartic proteinases, cathepsin E… 
Highly Cited
1996
Highly Cited
1996
Purification, characterization and immobilization of proteinase inhibitors from Stichodactyla helianthus.
Highly Cited
1995
Highly Cited
1995
Shared functions in vivo of a glycosyl-phosphatidylinositol-linked aspartyl protease, Mkc7, and the proprotein processing protease Kex2 in yeast.
The MKC7 gene was isolated as a multicopy suppressor of the cold-sensitive growth phenotype of a yeast kex2 mutant, which lacks… 
Review
1994
Review
1994
Multiple functions of pro‐parts of aspartic proteinase zymogens
Review
1992
Review
1992
Age Dependence of Ischaemic Heart Syndromes and the Contribution of Haemostatic Deviations
Highly Cited
1988
Highly Cited
1988
Primary structure of human pepsinogen C gene.
Highly Cited
1988
Highly Cited
1988
Synthesis and biological activity of some transition-state inhibitors of human renin.
A series of renin inhibitors containing the dipeptide transition state mimics (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-7… 
Highly Cited
1985
Highly Cited
1985
Pepstatin-derived inhibitors of aspartic proteinases. A close look at an apparent transition-state analogue inhibitor.
Highly Cited
1984
Highly Cited
1984
Computer graphics modelling of human renin
Highly Cited
1982
Highly Cited
1982
Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin.
Crystals of the molecular complex between the esterified tripeptide fragment of pepstatin and the aspartyl proteinase… 
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