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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.
The cDNAs of two new human membrane-associated aspartic proteases, memapsin 1 and memapsin 2, have been cloned and sequenced. The deduced amino acid sequences show that each contains the typical pre,Expand
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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor.
Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determinedExpand
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Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees.
  • K. Moser, B. Neas, +20 authors J. Harley
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 8 December 1998
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies against intracellular antigens including DNA, ribosomal P, Ro (SS-A), La (SS-B), and theExpand
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Subsite Specificity of Memapsin 2 (β-Secretase): Implications for Inhibitor Design†
Memapsin 2 is the protease known as β-secretase whose action on β-amyloid precursor protein leads to the production of the β-amyloid (Aβ) peptide. Since the accumulation of Aβ in the brain is a keyExpand
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β‐Secretase inhibitor GRL‐8234 rescues age‐related cognitive decline in APP transgenic mice
Alzheimer disease is intimately linked to an excess amount of amyloid‐β (Aβ) in the brain. Thus, therapeutic inhibition of Aβ production is an attractive clinical approach to treat this disease. HereExpand
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Human aspartic protease memapsin 2 cleaves the b-secretase site of b-amyloid precursor protein
The cDNAs of two new human membrane-associated aspartic proteases, memapsin 1 and memapsin 2, have been cloned and sequenced. The deduced amino acid sequences show that each contains the typical pre,Expand
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Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.
Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease that initiates the hydrolysis of beta-amyloid precursor protein (APP) leading to the production of amyloid-beta and the onset ofExpand
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Enzymic characteristics of secreted aspartic proteases of Candida albicans.
Candida yeasts are rarely infectious, but frequently cause life-threatening systemic infections in patients immunocompromised by AIDS or by immunosuppressive therapeutics. The secreted asparticExpand
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Crystal Structure of Memapsin 2 (β-Secretase) in Complex with an Inhibitor OM00-3†
The structure of the catalytic domain of human memapsin 2 bound to an inhibitor OM00-3 (Glu-Leu-Asp-Leu*Ala-Val-Glu-Phe, Ki = 0.3 nM, the asterisk denotes the hydroxyethylene transition-stateExpand
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Memapsin 2 (β‐secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2
Memapsin 2, or β‐secretase, is a membrane‐anchored aspartic protease that initiates the cleavage of β‐amyloid precursor protein (APP) leading to the production of β‐amyloid peptide in the brain andExpand
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