Aspartic Acid Endopeptidases

Known as: Endopeptidases, Aspartic Acid, Aspartic Endopeptidases, aspartic endopeptidase 
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1983-2017
0204019832017

Papers overview

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Highly Cited
2005
Highly Cited
2005
A transmembrane aspartyl protease termed beta-site APP cleavage enzyme 1 (BACE1) that cleaves the amyloid-beta precursor protein… (More)
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Highly Cited
2003
Highly Cited
2003
Alzheimer's disease is associated with increased production and aggregation of amyloid-beta (Abeta) peptides. Abeta peptides are… (More)
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Highly Cited
2003
Highly Cited
2003
gamma-Secretase is a membrane protein complex with an unusual aspartyl protease activity that catalyses the regulated… (More)
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Highly Cited
2002
Highly Cited
2002
The renin-angiotensin system (RAS) is critical for the control of blood pressure and salt balance in mammals. Renin is an… (More)
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Highly Cited
2002
Highly Cited
2002
Inhibition of amyloid beta-peptide (Abeta) production by blocking gamma-secretase activity is at present one of the most… (More)
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Highly Cited
2002
Highly Cited
2002
CONTEXT Amyloid plaques, a major pathological feature of Alzheimer disease (AD), are composed of an internal fragment of amyloid… (More)
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Highly Cited
2000
Highly Cited
2000
gamma-Secretase is a membrane-associated protease that cleaves within the transmembrane region of amyloid precursor protein to… (More)
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Highly Cited
2000
Highly Cited
2000
Cleavage of amyloid precursor protein (APP) by the beta- and gamma-secretases generates the amino and carboxy termini… (More)
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Highly Cited
1999
Highly Cited
1999
Accumulation of the amyloid-beta protein (Abeta) in the cerebral cortex is an early and invariant event in the pathogenesis of… (More)
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Highly Cited
1999
Highly Cited
1999
Mutations in the gene encoding the amyloid protein precursor (APP) cause autosomal dominant Alzheimer's disease. Cleavage of APP… (More)
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