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Aspartic Acid Endopeptidases

Known as: Endopeptidases, Aspartic Acid, Aspartic Endopeptidases, aspartic endopeptidase 
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Presenilins are the catalytic subunits of larger tetrameric γ-secretase complexes. The degradome of these aspartyl proteases… 
Highly Cited
2007
Highly Cited
2007
Candida glabrata is a yeast pathogen of humans. We have established a tissue culture model to analyze the interaction of C… 
Highly Cited
2000
Highly Cited
2000
Cleavage of amyloid precursor protein (APP) by the beta- and gamma-secretases generates the amino and carboxy termini… 
Highly Cited
2000
Highly Cited
2000
Endoproteolysis of β-amyloid precursor protein (βAPP) and Notch requires conserved aspartate residues in presenilins 1 and 2 (PS1… 
Highly Cited
2000
Highly Cited
2000
The amyloidogenic Abeta peptide is liberated from the amyloid precursor protein (APP) by two proteolytic activities, beta… 
Highly Cited
2000
Highly Cited
2000
Progressive cerebral amyloid beta-protein (A beta) deposition is believed to play a central role in the pathogenesis of Alzheimer… 
Highly Cited
1999
Highly Cited
1999
The amyloid beta-protein (Abeta), implicated in the pathogenesis of Alzheimer's disease (AD), is a proteolytic metabolite… 
Highly Cited
1995
Highly Cited
1995
The design and application of alpha-hydroxy phosphonates, a new class of transition state analogs, toward the discovery of novel… 
Highly Cited
1986
Highly Cited
1986
pep4 mutants of Saccharomyces cerevisiae accumulate inactive precursors of vacuolar hydrolases. The PEP4 gene was isolated from a…