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Aspartic Acid Endopeptidases

Known as: Endopeptidases, Aspartic Acid, Aspartic Endopeptidases, aspartic endopeptidase 
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
National Institutes of Health

Related topics

Related topics

49 relations

Narrower (40)

AXP protein, Yarrowia lipolyticaAspergillus oryzae carboxyl proteinaseBACE1 protein, humanBace protein, rat
Aspartic Acid ProteasesIn BloodProcess of secretionantagonists & inhibitors

Broader (1)

Endopeptidases

Papers overview

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Review
2010
Review
2010
Novel research horizons for presenilins and γ-secretases in cell biology and disease.
Presenilins are the catalytic subunits of larger tetrameric γ-secretase complexes. The degradome of these aspartyl proteases… 
Highly Cited
2007
Highly Cited
2007
A family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of Candida glabrata
Candida glabrata is a yeast pathogen of humans. We have established a tissue culture model to analyze the interaction of C… 
Highly Cited
2000
Highly Cited
2000
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Cleavage of amyloid precursor protein (APP) by the beta- and gamma-secretases generates the amino and carboxy termini… 
Highly Cited
2000
Highly Cited
2000
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
Endoproteolysis of β-amyloid precursor protein (βAPP) and Notch requires conserved aspartate residues in presenilins 1 and 2 (PS1… 
Highly Cited
2000
Highly Cited
2000
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase.
The amyloidogenic Abeta peptide is liberated from the amyloid precursor protein (APP) by two proteolytic activities, beta… 
Highly Cited
2000
Highly Cited
2000
L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity.
Progressive cerebral amyloid beta-protein (A beta) deposition is believed to play a central role in the pathogenesis of Alzheimer… 
Highly Cited
1999
Highly Cited
1999
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
The amyloid beta-protein (Abeta), implicated in the pathogenesis of Alzheimer's disease (AD), is a proteolytic metabolite… 
Highly Cited
1995
Highly Cited
1995
alpha-Hydroxy phosphinyl-based inhibitors of human renin.
The design and application of alpha-hydroxy phosphonates, a new class of transition state analogs, toward the discovery of novel… 
Highly Cited
1991
Highly Cited
1991
Dissociative inhibition of dimeric enzymes. Kinetic characterization of the inhibition of HIV-1 protease by its COOH-terminal tetrapeptide.
Highly Cited
1986
Highly Cited
1986
The PEP4 gene encodes an aspartyl protease implicated in the posttranslational regulation of Saccharomyces cerevisiae vacuolar hydrolases
pep4 mutants of Saccharomyces cerevisiae accumulate inactive precursors of vacuolar hydrolases. The PEP4 gene was isolated from a… 
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