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Aspartic Acid Endopeptidases

Known as: Endopeptidases, Aspartic Acid, Aspartic Endopeptidases, aspartic endopeptidase 
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Presenilins are the catalytic subunits of larger tetrameric γ-secretase complexes. The degradome of these aspartyl proteases… Expand
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Highly Cited
2008
Highly Cited
2008
Presenilin, the catalytic component of the gamma-secretase complex, type IV prepilin peptidases, and signal peptide peptidase… Expand
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Highly Cited
2007
Highly Cited
2007
Candida glabrata is a yeast pathogen of humans. We have established a tissue culture model to analyze the interaction of C… Expand
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Highly Cited
2005
Highly Cited
2005
Amyloid plaques are formed by aggregates of amyloid-beta-peptide, a 37-43-amino acid fragment (primarily Abeta(40) and Abeta(42… Expand
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Highly Cited
2002
Highly Cited
2002
Presenilin heterodimers apparently contain the active site of gamma-secretase, a polytopic aspartyl protease involved in the… Expand
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Highly Cited
2000
Highly Cited
2000
Cleavage of amyloid precursor protein (APP) by the beta- and gamma-secretases generates the amino and carboxy termini… Expand
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Highly Cited
2000
Highly Cited
2000
The amyloidogenic Abeta peptide is liberated from the amyloid precursor protein (APP) by two proteolytic activities, beta… Expand
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Highly Cited
2000
Highly Cited
2000
Progressive cerebral amyloid beta-protein (A beta) deposition is believed to play a central role in the pathogenesis of Alzheimer… Expand
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Highly Cited
2000
Highly Cited
2000
Endoproteolysis of β-amyloid precursor protein (βAPP) and Notch requires conserved aspartate residues in presenilins 1 and 2 (PS1… Expand
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Highly Cited
1999
Highly Cited
1999
The amyloid beta-protein (Abeta), implicated in the pathogenesis of Alzheimer's disease (AD), is a proteolytic metabolite… Expand
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