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Aspartic Acid Endopeptidases

Known as: Endopeptidases, Aspartic Acid, Aspartic Endopeptidases, aspartic endopeptidase 
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Presenilins are the catalytic subunits of larger tetrameric γ-secretase complexes. The degradome of these aspartyl proteases… Expand
Highly Cited
2007
Highly Cited
2007
Candida glabrata is a yeast pathogen of humans. We have established a tissue culture model to analyze the interaction of C… Expand
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Review
2002
Review
2002
Biochemical and genetic evidence indicates the balance of biogenesis/clearance of Abeta amyloid peptides is altered in Alzheimer… Expand
Highly Cited
2000
Highly Cited
2000
Cleavage of amyloid precursor protein (APP) by the beta- and gamma-secretases generates the amino and carboxy termini… Expand
Highly Cited
2000
Highly Cited
2000
Endoproteolysis of β-amyloid precursor protein (βAPP) and Notch requires conserved aspartate residues in presenilins 1 and 2 (PS1… Expand
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Highly Cited
2000
Highly Cited
2000
The amyloidogenic Abeta peptide is liberated from the amyloid precursor protein (APP) by two proteolytic activities, beta… Expand
Highly Cited
1999
Highly Cited
1999
The amyloid beta-protein (Abeta), implicated in the pathogenesis of Alzheimer's disease (AD), is a proteolytic metabolite… Expand
Highly Cited
1995
Highly Cited
1995
The design and application of alpha-hydroxy phosphonates, a new class of transition state analogs, toward the discovery of novel… Expand
Highly Cited
1995
Highly Cited
1995
Human immunodeficiency virus type 1 (HIV-1) variants with reduced sensitivity to the hydroxyethylamino sulfonamide protease… Expand
Highly Cited
1986
Highly Cited
1986
pep4 mutants of Saccharomyces cerevisiae accumulate inactive precursors of vacuolar hydrolases. The PEP4 gene was isolated from a… Expand