Aspartic Acid Endopeptidases

A transmembrane aspartyl protease termed beta-site APP cleavage enzyme 1 (BACE1) that cleaves the amyloid-beta precursor protein… (More)

Alzheimer's disease is associated with increased production and aggregation of amyloid-beta (Abeta) peptides. Abeta peptides are… (More)

gamma-Secretase is a membrane protein complex with an unusual aspartyl protease activity that catalyses the regulated… (More)

The renin-angiotensin system (RAS) is critical for the control of blood pressure and salt balance in mammals. Renin is an… (More)

Inhibition of amyloid beta-peptide (Abeta) production by blocking gamma-secretase activity is at present one of the most… (More)

CONTEXT Amyloid plaques, a major pathological feature of Alzheimer disease (AD), are composed of an internal fragment of amyloid… (More)

gamma-Secretase is a membrane-associated protease that cleaves within the transmembrane region of amyloid precursor protein to… (More)

Cleavage of amyloid precursor protein (APP) by the beta- and gamma-secretases generates the amino and carboxy termini… (More)

Accumulation of the amyloid-beta protein (Abeta) in the cerebral cortex is an early and invariant event in the pathogenesis of… (More)

Mutations in the gene encoding the amyloid protein precursor (APP) cause autosomal dominant Alzheimer's disease. Cleavage of APP… (More)