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- Publications
- Influence
Crystal structures of the helix-loop-helix calcium-binding proteins.
- N. Strynadka, M. James
- Chemistry, Medicine
- Annual review of biochemistry
- 1989
Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7*
- M. Fraser, M. Fujinaga, +4 authors M. James
- Biology, Medicine
- Journal of Biological Chemistry
- 25 June 2004
Several serotypes of Escherichia coli produce protein toxins closely related to Shiga toxin (Stx) from Shigella dysenteriae serotype 1. These Stx-producing E. coli cause outbreaks of hemorrhagic… Expand
Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution.
- M. Fraser, M. Chernaia, Y. Kozlov, M. James
- Medicine
- Nature structural biology
- 1994
Shigella dysenteriae is the pathogen responsible for the severe form of dysentery in humans. It produces Shiga toxin, the prototype of a family of closely related bacterial protein toxins. We have… Expand
Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution
- N. Strynadka, H. Adachi, +5 authors M. James
- Chemistry, Medicine
- Nature
- 22 October 1992
The X-ray crystal structure of the molecular complex of penicillin G with a deacylation-defective mutant of the RTEM-1 β-lactamase from Escherichia coli shows how these antibiotics are recognized and… Expand
Crystal Structures of Active and Inactive Conformations of a Caliciviral RNA-dependent RNA Polymerase*
- K. Ng, M. Cherney, +4 authors M. James
- Biology, Medicine
- The Journal of Biological Chemistry
- 11 January 2002
The structure of the RNA-dependent RNA polymerase (RdRP) from the rabbit hemorrhagic disease virus has been determined by x-ray crystallography to a 2.5-Å resolution. The overall structure resembles… Expand
Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors*
- B. K. Biswal, M. Cherney, +6 authors M. James
- Biology, Medicine
- Journal of Biological Chemistry
- 6 May 2005
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus (HCV) from two crystal forms have been determined. Similar to the three-dimensional structures of HCV… Expand
Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases
- M. Allaire, M. Chernaia, B. Malcolm, M. James
- Biology, Medicine
- Nature
- 5 May 1994
THE picornavirus family includes several pathogens such as poliovirus, rhinovirus (the major cause of the common cold), hepat-itis A virus and the foot-and-mouth disease virus. Picornaviral proteins… Expand
The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition.
- E. Bergmann, S. Mosimann, M. Chernaia, B. Malcolm, M. James
- Biology, Medicine
- Journal of virology
- 1 March 1997
The virally encoded 3C proteinases of picornaviruses process the polyprotein produced by the translation of polycistronic viral mRNA. The X-ray crystallographic structure of a catalytically active… Expand
Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes
- A. R. Khan, M. James
- Chemistry, Medicine
- Protein science : a publication of the Protein…
- 1 April 1998
Proteolytic enzymes are synthesized as inactive precursors, or “zymogens,” to prevent unwanted protein degradation, and to enable spatial and temporal regulation of proteolytic activity. Upon sorting… Expand
The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies.
- M. Fujinaga, M. Chernaia, R. Halenbeck, K. Koths, M. James
- Chemistry, Medicine
- Journal of molecular biology
- 16 August 1996
The crystal structure of PR3, a serine proteinase from the azurophilic granules of human polymorphonuclear neutrophils, has been solved by molecular replacement using the human leukocyte elastase… Expand
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