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Crystal structures of the helix-loop-helix calcium-binding proteins.
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Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7*
Several serotypes of Escherichia coli produce protein toxins closely related to Shiga toxin (Stx) from Shigella dysenteriae serotype 1. These Stx-producing E. coli cause outbreaks of hemorrhagicExpand
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Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution.
Shigella dysenteriae is the pathogen responsible for the severe form of dysentery in humans. It produces Shiga toxin, the prototype of a family of closely related bacterial protein toxins. We haveExpand
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Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution
The X-ray crystal structure of the molecular complex of penicillin G with a deacylation-defective mutant of the RTEM-1 β-lactamase from Escherichia coli shows how these antibiotics are recognized andExpand
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Crystal Structures of Active and Inactive Conformations of a Caliciviral RNA-dependent RNA Polymerase*
The structure of the RNA-dependent RNA polymerase (RdRP) from the rabbit hemorrhagic disease virus has been determined by x-ray crystallography to a 2.5-Å resolution. The overall structure resemblesExpand
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Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors*
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus (HCV) from two crystal forms have been determined. Similar to the three-dimensional structures of HCVExpand
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Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases
THE picornavirus family includes several pathogens such as poliovirus, rhinovirus (the major cause of the common cold), hepat-itis A virus and the foot-and-mouth disease virus. Picornaviral proteinsExpand
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The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition.
The virally encoded 3C proteinases of picornaviruses process the polyprotein produced by the translation of polycistronic viral mRNA. The X-ray crystallographic structure of a catalytically activeExpand
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Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes
  • A. R. Khan, M. James
  • Chemistry, Medicine
  • Protein science : a publication of the Protein…
  • 1 April 1998
Proteolytic enzymes are synthesized as inactive precursors, or “zymogens,” to prevent unwanted protein degradation, and to enable spatial and temporal regulation of proteolytic activity. Upon sortingExpand
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The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies.
The crystal structure of PR3, a serine proteinase from the azurophilic granules of human polymorphonuclear neutrophils, has been solved by molecular replacement using the human leukocyte elastaseExpand
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