M. James

Publications524
h-index76
Citations17,983
Highly Influential Citations681
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • A. Aguzzi
  • 759 Publications • 52,275 Citations
  • M. Cherney
  • 188 Publications • 4,043 Citations
  • J. Vederas
  • 473 Publications • 18,320 Citations
  • R. Huber
  • 1,188 Publications • 85,813 Citations
  • Publications
  • Influence
Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7*
TLDR
The crystal structure of Stx2 from E. coli O157:H7 was determined and it was found that, in contrast to Stx, the active site of the A-subunit of StX2 is accessible in the holotoxin, and a molecule of formic acid and a water molecule mimic the binding of the adenine base of the substrate.
View on Publisher
Crystal structures of the helix-loop-helix calcium-binding proteins.
View on PubMed
Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution.
TLDR
The structure of the holotoxin, an AB5 hexamer, is determined by X-ray crystallography and it is found that the active site in the bacterial Holotoxin is blocked by a segment of polypeptide chain.
View on PubMed
Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution
The X-ray crystal structure of the molecular complex of penicillin G with a deacylation-defective mutant of the RTEM-1 β-lactamase from Escherichia coli shows how these antibiotics are recognized and…
View on Springer
Crystal Structures of Active and Inactive Conformations of a Caliciviral RNA-dependent RNA Polymerase*
TLDR
Comparisons between the structures of the alternate conformational states of rabbit hemorrhagic disease virus RdRP and the structure of RdRPs from hepatitis C virus and polio virus suggest novel structure-function relationships in this medically important class of enzymes.
View on Publisher
Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases
TLDR
The overall architecture of HAV-3C reveals a fold resembling that of the chymotrypsin family of serine proteinases, which is consistent with earlier predictions7,8.
View on Springer
The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition
TLDR
The X-ray crystallographic structure of a catalytically active mutant of the hepatitis A virus (HAV) 3C proteinase (C24S) has been determined and the glutamine specificity for P1 residues of substrate cleavage sites is attributed to the presence of a highly conserved His 191 in the S1 pocket.
View on ASMUSA
Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors*
TLDR
The structures of the NS5B polymerase/non-nucleoside inhibitor complexes bind at a common binding site, which is nearly 35 Å away from the polymerase active site and is located in the thumb domain, and the enzyme inhibitor complexes are stabilized by hydrogen bonding and van der Waals interactions.
View on Publisher
The POM Monoclonals: A Comprehensive Set of Antibodies to Non-Overlapping Prion Protein Epitopes
TLDR
A comprehensive collection of monoclonal antibodies denoted POM1 to POM19 and directed against many different epitopes of mouse PrPC, which represents a unique set of reagents allowing for studies with a variety of techniques, including western blotting, ELISA, immunoprecipitation, conformation-dependent immunoassays, and plasmon surface plasMon resonance-based assays.
View on PubMed
The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein
Prion infections cause lethal neurodegeneration. This process requires the cellular prion protein (PrPC; ref. 1), which contains a globular domain hinged to a long amino-proximal flexible tail. Here…
View on Nature
...
...