M. James

Publications530
h-index74
Citations17,729
Highly Influential Citations639
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • M. Cherney
  • 175 Publications • 3,630 Citations
  • A. Aguzzi
  • 493 Publications • 40,025 Citations
  • J. Vederas
  • 455 Publications • 15,082 Citations
  • W. Bode
  • 477 Publications • 30,655 Citations
  • Publications
  • Influence
Crystal structures of the helix-loop-helix calcium-binding proteins.
  • 723
  • 32
Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7*
Several serotypes of Escherichia coli produce protein toxins closely related to Shiga toxin (Stx) from Shigella dysenteriae serotype 1. These Stx-producing E. coli cause outbreaks of hemorrhagic… Expand
  • 265
  • 32
Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution.
Shigella dysenteriae is the pathogen responsible for the severe form of dysentery in humans. It produces Shiga toxin, the prototype of a family of closely related bacterial protein toxins. We have… Expand
  • 154
  • 24
Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution
The X-ray crystal structure of the molecular complex of penicillin G with a deacylation-defective mutant of the RTEM-1 β-lactamase from Escherichia coli shows how these antibiotics are recognized and… Expand
  • 441
  • 18
Crystal Structures of Active and Inactive Conformations of a Caliciviral RNA-dependent RNA Polymerase*
The structure of the RNA-dependent RNA polymerase (RdRP) from the rabbit hemorrhagic disease virus has been determined by x-ray crystallography to a 2.5-Å resolution. The overall structure resembles… Expand
  • 158
  • 17
  • PDF
Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors*
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus (HCV) from two crystal forms have been determined. Similar to the three-dimensional structures of HCV… Expand
  • 177
  • 15
Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases
THE picornavirus family includes several pathogens such as poliovirus, rhinovirus (the major cause of the common cold), hepat-itis A virus and the foot-and-mouth disease virus. Picornaviral proteins… Expand
  • 269
  • 14
The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition.
The virally encoded 3C proteinases of picornaviruses process the polyprotein produced by the translation of polycistronic viral mRNA. The X-ray crystallographic structure of a catalytically active… Expand
  • 140
  • 13
Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes
  • A. R. Khan, M. James
  • Chemistry, Medicine
  • Protein science : a publication of the Protein…
  • 1 April 1998
Proteolytic enzymes are synthesized as inactive precursors, or “zymogens,” to prevent unwanted protein degradation, and to enable spatial and temporal regulation of proteolytic activity. Upon sorting… Expand
  • 407
  • 12
The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies.
The crystal structure of PR3, a serine proteinase from the azurophilic granules of human polymorphonuclear neutrophils, has been solved by molecular replacement using the human leukocyte elastase… Expand
  • 139
  • 12
...
1
2
3
4
5
...