CATHEPSIN D

Known as: CTSD, Cathepsin D [Chemical/Ingredient], Cathepsin D (Lysosomal Aspartyl Protease) 
An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1966-2018
05010019662018

Papers overview

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Highly Cited
2007
Highly Cited
2007
Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery… (More)
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Highly Cited
2006
Highly Cited
2006
Congenital neuronal ceroid-lipofuscinosis (NCL) is a devastating inherited neurodegenerative disorder of unknown metabolic basis… (More)
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Highly Cited
2004
Highly Cited
2004
AbstractAcidic noncaspase proteases-like cathepsins have been introduced as novel mediators of apoptosis. A clear role for these… (More)
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Highly Cited
2001
Highly Cited
2001
It has been suggested that lysosomes and the lysosomal proteases cathepsin D and B act as proapoptotic mediators of apoptosis, in… (More)
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Highly Cited
2000
Highly Cited
2000
Cathepsin D-deficient (CD-/-) mice have been shown to manifest seizures and become blind near the terminal stage [approximately… (More)
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Highly Cited
1999
Highly Cited
1999
Ceramide has been recognized as a common intracellular second messenger for various cytokines, growth factors and other stimuli… (More)
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Highly Cited
1998
Highly Cited
1998
Stable BHK cell lines inducibly expressing wild-type or dominant negative mutant forms of the rab7 GTPase were isolated and used… (More)
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Highly Cited
1998
Highly Cited
1998
Exposing neonatal rat heart myocytes to the redox cycling quinone naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) for 15 to 45… (More)
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Highly Cited
1996
Highly Cited
1996
A functional approach of gene cloning was applied to HeLa cells in an attempt to isolate positive mediators of programmed cell… (More)
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Highly Cited
1990
Highly Cited
1990
We investigated the possibility that cathepsin D, an estrogen-induced lysosomal protease, might have value as a prognostic factor… (More)
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