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CATHEPSIN D

Known as: CTSD, Cathepsin D [Chemical/Ingredient], Cathepsin D (Lysosomal Aspartyl Protease) 
An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in… 
National Institutes of Health

Related topics

Related topics

30 relations
Angiogenic ProcessAspartic Acid ProteasesBreast CarcinomaCTSD gene

Broader (1)

Aspartic Acid Endopeptidases

Narrower (5)

Ctsd protein, mouseNEURONAL CEROID LIPOFUSCINOSIS DUE TO CATHEPSIN D DEFICIENCYprocathepsin Dshort recombinant human pseudocathepsin D

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo
Abstract Loss of function mutations in progranulin (GRN) cause frontotemporal dementia, but how GRN haploinsufficiency causes… 
Highly Cited
2011
Highly Cited
2011
AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers largely due to disseminated disease at the time of… 
Highly Cited
2010
Highly Cited
2010
Osteopontin Is Cleaved at Multiple Sites Close to Its Integrin-binding Motifs in Milk and Is a Novel Substrate for Plasmin and Cathepsin D*
Osteopontin (OPN) is a highly modified integrin-binding protein present in most tissues and body fluids where it has been… 
Highly Cited
2006
Highly Cited
2006
Cathepsin D deficiency is associated with a human neurodegenerative disorder.
Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and… 
Highly Cited
2004
Highly Cited
2004
Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation
AbstractAcidic noncaspase proteases-like cathepsins have been introduced as novel mediators of apoptosis. A clear role for these… 
Highly Cited
2000
Highly Cited
2000
Ceramide as an activator lipid of cathepsin D.
We have identified the aspartic protease cathepsin D as a novel intracellular target protein for the lipid second messenger… 
Highly Cited
1998
Highly Cited
1998
Mutant Rab7 Causes the Accumulation of Cathepsin D and Cation-independent Mannose 6–Phosphate Receptor in an Early Endocytic Compartment
Stable BHK cell lines inducibly expressing wild-type or dominant negative mutant forms of the rab7 GTPase were isolated and used… 
Highly Cited
1994
Highly Cited
1994
Characterization of the proximal estrogen-responsive element of human cathepsin D gene.
Cathepsin D, a lysosomal proteinase, is induced by estrogens in mammary cancer cells where its concentration is correlated with a… 
Highly Cited
1976
Highly Cited
1976
The effects of proteolytic enzymes on the mechanical properties of adult human articular cartilage.
Highly Cited
1971
Highly Cited
1971
Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown.
1. Antisera were raised against lysosomal cathepsin D of man, chicken and rabbit. 2. The antisera were found to be specific and… 
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