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CATHEPSIN D

Known as: CTSD, Cathepsin D [Chemical/Ingredient], Cathepsin D (Lysosomal Aspartyl Protease) 
An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in… 
National Institutes of Health

Related topics

Related topics

30 relations
Angiogenic ProcessAspartic Acid ProteasesBreast CarcinomaCTSD gene

Broader (1)

Aspartic Acid Endopeptidases

Narrower (5)

Ctsd protein, mouseNEURONAL CEROID LIPOFUSCINOSIS DUE TO CATHEPSIN D DEFICIENCYprocathepsin Dshort recombinant human pseudocathepsin D

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Cathepsin D, but not cathepsin E, degrades desmosomes during epidermal desquamation
Background  We previously reported that an ambient aspartic proteinase is crucial to desquamation of the stratum corneum at pH 5… 
Highly Cited
1996
Highly Cited
1996
Bovine milk procathepsin D and cathepsin D: coagulation and milk protein degradation
Summary Cathepsin D is an indigenous aspartic proteinase in bovine milk. By competitive enzyme-linked immunosorbent assay the… 
Highly Cited
1995
Highly Cited
1995
Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors.
Cathepsin D, a lysosomal protease, is overexpressed in primary breast cancer and associated with increased risk of metastasis. We… 
1992
1992
Lysosomal enzyme phosphorylation. I. Protein recognition determinants in both lobes of procathepsin D mediate its interaction with UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase…
1990
1990
Microtubule depolymerization inhibits transport of cathepsin D from the Golgi apparatus to lysosomes.
Lysosomes as well as a prelysosomal compartment rich in the mannose 6-phosphate receptor are clustered close to the Golgi… 
1985
1985
Cathepsin D precursors in clathrin-coated organelles from human fibroblasts
Coated vesicles were isolated from metabolically labeled human fibroblasts with the aid of affinity-purified antibodies against… 
Highly Cited
1985
Highly Cited
1985
Biosynthesis and intracellular transport of alpha-glucosidase and cathepsin D in normal and mutant human fibroblasts.
In order to study the intracellular localization of the proteolytic processing steps in the maturation of alpha-glucosidase and… 
Highly Cited
1984
Highly Cited
1984
Role of thiols, pH and cathepsin D in the lysosomal catabolism of serum albumin.
Attempts were made to assess the role of thiols and to determine the cathepsins involved in the degradation of serum albumin in… 
Highly Cited
1976
Highly Cited
1976
Renin activity in dog brain: enzymological similarity to cathepsin D.
The distribution and biochemical properties of the renin activity present in the dog brain were compared with those of the… 
Highly Cited
1971
Highly Cited
1971
Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown.
1. Antisera were raised against lysosomal cathepsin D of man, chicken and rabbit. 2. The antisera were found to be specific and… 
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