BACE1 protein, human

Known as: Beta-Site Amyloid Beta A4 Precursor Protein-Cleaving Enzyme 1, beta-site APP-cleaving enzyme 1, human, APP Beta-Secretase 
Beta-secretase 1 (501 aa, ~56 kDa) is encoded by the human BACE1 gene. This protein plays a role in the proteolysis of ectodomains of membrane… (More)
National Institutes of Health

Papers overview

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Review
2009
Review
2009
beta-Secretase (beta-site amyloid precursor protein cleaving enzyme 1; BACE1) has been identified as the rate limiting enzyme for… (More)
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Highly Cited
2007
Highly Cited
2007
The tumor necrosis factor type 1 death receptor (TNFR1) contributes to apoptosis. TNFR1, a subgroup of the TNFR superfamily… (More)
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Highly Cited
2005
Highly Cited
2005
Memapsin 2 (BACE, beta-secretase) is a membrane-associated aspartic protease that initiates the hydrolysis of beta-amyloid… (More)
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2004
2004
We have previously reported structure-based design of memapsin 2 (beta-secretase) inhibitors with high potency. Here we show that… (More)
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2001
2001
In insects, the transport of airborne, hydrophobic odorants and pheromones through the sensillum lymph is generally thought to be… (More)
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Highly Cited
2000
Highly Cited
2000
The cDNAs of two new human membrane-associated aspartic proteases, memapsin 1 and memapsin 2, have been cloned and sequenced. The… (More)
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2000
2000
 
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Highly Cited
2000
Highly Cited
2000
Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in… (More)
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2000
2000
The catalytic (C) subunit of protein kinase A functions both in the cytoplasm and the nucleus. A major charge variant… (More)
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Highly Cited
1999
Highly Cited
1999
The Alzheimer's disease beta-amyloid peptide (Abeta) is produced by excision from the type 1 integral membrane glycoprotein… (More)
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