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BACE1 protein, human

Known as: Beta-Site Amyloid Beta A4 Precursor Protein-Cleaving Enzyme 1, beta-site APP-cleaving enzyme 1, human, APP Beta-Secretase 
Beta-secretase 1 (501 aa, ~56 kDa) is encoded by the human BACE1 gene. This protein plays a role in the proteolysis of ectodomains of membrane… 
National Institutes of Health

Related topics

Related topics

15 relations
Alzheimer's Disease Pathway KEGGAspartic Acid ProteasesBACE1 geneEnzyme Gene

Broader (2)

Aspartic Acid Endopeptidasessecretase

Narrower (2)

I-127 BACE isoform, humanI-476 BACE isoform, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
A systematic review on anti-Alzheimer's disease activity of prescription Kangen-karyu.
Traditional Chinese and Japanese medicines have become prime sources of drug discovery and there is a pressing need to… 
2019
2019
Performance evaluation of molecular docking and free energy calculations protocols using the D3R Grand Challenge 4 dataset
Using the D3R Grand Challenge 4 dataset containing Beta-secretase 1 (BACE) and Cathepsin S (CatS) inhibitors, we have evaluated… 
2007
2007
Study of memapsin 2 (β-secretase) and strategy of inhibitor design
The discovery that β-secretase is a membrane-anchored aspartic protease memapsin 2 has stimulated much interest in the design and… 
2006
2006
Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors.
Structure-based design, synthesis, and X-ray structure of protein-ligand complexes of memapsin 2 are described. The inhibitors… 
2005
2005
A continuous time-resolved fluorescence assay for identification of BACE1 inhibitors.
The aspartic protease beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) mediates the production of the neurotoxic… 
2002
2002
Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.
The structure of the catalytic domain of human memapsin 2 bound to an inhibitor OM00-3 (Glu-Leu-Asp-LeuAla-Val-Glu-Phe, K(i) = 0… 
Review
2002
Review
2002
Memapsin 2 (beta-secretase) as a therapeutic target.
As beta-secretase, memapsin 2 cleaves amyloid-beta precursor protein, which leads ultimately to the onset of Alzheimer's disease… 
1989
1989
Purification and some properties of thiosulphate-cleaving enzyme from Thiobacillus novellus.
A thiosulphate-cleaving enzyme was purified from Thiobacillus novellus and some of its properties studied. The enzyme showed an… 
1977
1977
Demonstration of a pyroglutamyl residue at the N terminus of the B-chain of porcine relaxin.
1976
1976
[Primary structure of the casein macropeptide of caprine kappa casein].
The amino acid sequence of caprine CMP, the negatively charged C-terminal fragment released by chymosin (rennin EC 3.4.23.4) from… 
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