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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor.
The crystal structure of the protease domain of human memapsin 2 complexed to an eight-residue inhibitor at 1.9 angstrom resolution is determined and it is found that the active site of memapin 2 is more open and less hydrophobic than that of other human aspartic proteases. Expand
Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).
- J. Cordell, B. Falini, +6 authors D. Mason
- Chemistry, Medicine
- The journal of histochemistry and cytochemistry…
- 1 February 1984
The APAAP technique was found particularly suitable for labeling cell smears and for detecting low numbers of antigen-bearing cells in a specimen and could be used in conjunction with immunoperoxidase methods for double immunoenzymatic staining. Expand
Current knowledge on the distribution of arsenic in groundwater in five states of India
- R. Nickson, C. Sengupta, +17 authors P. Deverill
- Environmental Science, Medicine
- Journal of environmental science and health. Part…
- 16 October 2007
The most up-to-date picture of areas known to be affected by arsenic in groundwater in the Indian portion of the Ganges-Brahmaputra river basin is provided. Expand
Effect of arsenic contamination on microbial biomass and its activities in arsenic contaminated soils of Gangetic West Bengal, India.
It is suggested that the microbial biomass, fluorescein diacetate and dehydrogenase activity alone and expressed on a soil organic matter basis along with the soil respiration parameters can be helpful in assessing the effects of arsenic on the size and activity of microbial biomass in soils. Expand
Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators.
- A. Ghosh, W. Yuan, Y. Mori, Chen Sj, J. Varga
- Biology, Medicine
- The Journal of biological chemistry
- 6 April 2001
It is reported that IFN-gamma abrogates TGF-beta-stimulated COL1A2 transcription in fibroblasts by inhibiting Smad activities, implicating a novel mechanism to account for antagonistic interaction of Smad and Jak-Stat pathways in regulation of target genes. Expand
Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth.
- A. Ghosh, R. Steele, K. Meyer, R. Ray, R. Ray
- Biology, Medicine
- The Journal of general virology
- 1 May 1999
Results suggested that NS5A protein represses transcription of the cell cycle regulatory gene p21WAF1, while it activates the human proliferating cell nuclear antigen gene in murine fibroblasts and human hepatoma cells. Expand
PHYTOCHEMICAL INVESTIGATION AND CHROMATOGRAPHIC EVALUATION OF THE DIFFERENT EXTRACTS OF TUBER OF AMORPHAPHALLUS PAEONIIFOLIUS (ARACEAE)
The present study was aimed to investigate phytochemicals present in the tuber extract of Amorphaphallus paeoniifolius and development of new solvent system for thin layer chromatography of petroleum… Expand
Use of flyash in agriculture: a way to improve soil fertility and its productivity.
Leishmania donovani: amastigote inhibition and mode of action of berberine.
Berberine, an alkaloid from Berberis aristata Linnaeus, may be a useful drug for the treatment of visceral leishmaniasis and was found to interact in vitro with nuclear DNA from L. donovani promastigotes. Expand