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BACE1 gene

Known as: BACE, SECRETASE, BETA, beta-site APP-cleaving enzyme 1 
This gene plays a role in protein cleavage.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be… Expand
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Highly Cited
2008
Highly Cited
2008
Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known… Expand
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Highly Cited
2008
Highly Cited
2008
Recent efforts have revealed that numerous protein-coding messenger RNAs have natural antisense transcript partners, most of… Expand
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Highly Cited
2006
Highly Cited
2006
  • X. Sun, G. He, +6 authors W. Song
  • Proceedings of the National Academy of Sciences
  • 2006
  • Corpus ID: 34147227
The molecular mechanism underlying the pathogenesis of the majority of cases of sporadic Alzheimer's disease (AD) is unknown. A… Expand
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Highly Cited
2004
Highly Cited
2004
beta-site APP cleaving enzyme 1 (BACE1) is the beta-secretase enzyme required for generating pathogenic beta-amyloid (Abeta… Expand
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Highly Cited
2003
Highly Cited
2003
Alzheimer's disease is associated with increased production and aggregation of amyloid-β (Aβ) peptides. Aβ peptides are derived… Expand
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Highly Cited
2001
Highly Cited
2001
Two β-secretases, BACE1 and BACE2, are involved in generation of Alzheimer's disease Aβ peptides. We report that secretion of A… Expand
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Highly Cited
2001
Highly Cited
2001
Mice deficient in BACE1 (beta-site APP cleaving enzyme 1) are healthy, fertile and appear normal in gross anatomy, tissue… Expand
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Highly Cited
2001
Highly Cited
2001
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid plaques and neurofibrillary… Expand
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Highly Cited
1999
Highly Cited
1999
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation… Expand
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