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BACE1 gene

Known as: BACE, SECRETASE, BETA, beta-site APP-cleaving enzyme 1 
This gene plays a role in protein cleavage.
National Institutes of Health

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6 relations
BACE1 ANTISENSE RNA: BACE1ASBACE1 protein, humanHydrolysisProteolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
Bispecific antibodies engineered to both bind to the primate transferrin receptor and inhibit β-secretase are taken up by the… 
Review
2010
Review
2010
Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.
Alzheimer disease is characterized by the accumulation of abnormally folded protein fragments, i.e., amyloid beta peptide (Abeta… 
Highly Cited
2008
Highly Cited
2008
Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice
β-Site APP-cleaving enzyme 1 (BACE1) is required for the penultimate cleavage of the amyloid-β precursor protein (APP) leading to… 
Highly Cited
2007
Highly Cited
2007
Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity
Highly Cited
2007
Highly Cited
2007
BACE1 regulates voltage-gated sodium channels and neuronal activity
BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to… 
Highly Cited
2005
Highly Cited
2005
Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice*
β-Secretase (BACE1) is the rate-limiting protease for the generation of the amyloid β-peptide (Aβ) in Alzheimer disease. Mice in… 
Highly Cited
2005
Highly Cited
2005
Oxidative stress potentiates BACE1 gene expression and Aβ generation
Summary.Alzheimer’s Disease (AD) is the most common neurodegenerative disorder leading to dementia and its prevalence increases… 
Highly Cited
2005
Highly Cited
2005
Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited
The sequential enzymatic actions of β-APP cleaving enzyme 1 (BACE1), presenilins (PS), and other proteins of the γ-secretase… 
Highly Cited
2003
Highly Cited
2003
The Cell Adhesion Protein P-selectin Glycoprotein Ligand-1 Is a Substrate for the Aspartyl Protease BACE1*
The aspartyl protease BACE1 cleaves the amyloid precursor protein and the sialyltransferase ST6Gal I and is important in the… 
Highly Cited
2000
Highly Cited
2000
A Furin-like Convertase Mediates Propeptide Cleavage of BACE, the Alzheimer's β-Secretase*
The novel transmembrane aspartic protease BACE (for Beta-site APP CleavingEnzyme) is the β-secretase that cleaves amyloid… 
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