BACE1 gene

Known as: BACE, SECRETASE, BETA, beta-site APP-cleaving enzyme 1 
This gene plays a role in protein cleavage.
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Alzheimer’s disease (AD) is a major form of senile dementia, characterized by progressive memory and neuronal loss combined with… (More)
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Highly Cited
2008
Highly Cited
2008
Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known… (More)
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Highly Cited
2008
Highly Cited
2008
beta-Site APP-cleaving enzyme 1 (BACE1) is required for the penultimate cleavage of the amyloid-beta precursor protein (APP… (More)
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Highly Cited
2008
Highly Cited
2008
beta-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for beta-amyloid (Abeta) production, is elevated in Alzheimer's… (More)
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Highly Cited
2007
Highly Cited
2007
Evidence suggests that beta-amyloid (Abeta) peptide triggers a pathogenic cascade leading to neuronal loss in Alzheimer's disease… (More)
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Highly Cited
2006
Highly Cited
2006
The molecular mechanism underlying the pathogenesis of the majority of cases of sporadic Alzheimer's disease (AD) is unknown. A… (More)
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Highly Cited
2006
Highly Cited
2006
Although BACE1 (beta-site amyloid precursor protein-cleaving enzyme 1) is essential for the generation of amyloid-b peptide in… (More)
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Highly Cited
2006
Highly Cited
2006
Bace1 is an endopeptidase that cleaves the amyloid precursor protein at the β-secretase site. Apart from this cleavage, the… (More)
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Highly Cited
2004
Highly Cited
2004
Alzheimer’s Disease (AD) is the most common neurodegenerative disorder leading to dementia and its prevalence increases with age… (More)
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Highly Cited
2004
Highly Cited
2004
beta-site APP cleaving enzyme 1 (BACE1) is the beta-secretase enzyme required for generating pathogenic beta-amyloid (Abeta… (More)
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