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secretase

Known as: Amyloid Precursor Protein Secretases [Chemical/Ingredient], Amyloid Precursor Protein Secretase, Secretase, APP 
Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified… 
National Institutes of Health

Related topics

Related topics

16 relations

Narrower (6)

ADAM10 protein, humanBACE1 protein, humanBace protein, ratalpha-Secretase
CTSB geneCathepsins BIn BloodProcess of secretion

Broader (1)

Endopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Structure, mechanism and inhibition of γ-secretase and presenilin-like proteases
Abstract Presenilin is the catalytic component of γ-secretase, a complex aspartyl protease and a founding member of intramembrane… 
Highly Cited
2008
Highly Cited
2008
In vitro validation of γ-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia
Activating NOTCH-1 mutations are common in T-cell acute lymphoblastic leukemia. Inhibition of NOTCH-1 signaling by γ-secretase… 
2008
2008
Novel non-peptidic and small-sized BACE1 inhibitors.
Highly Cited
2006
Highly Cited
2006
Heparin derivatives as inhibitors of BACE-1, the Alzheimer's beta-secretase, with reduced activity against factor Xa and other proteases.
Heparan sulfate (HS) regulates processing of the amyloid precursor protein by the Alzheimer's beta-secretase (BACE-1). An HS… 
2006
2006
Ensemble Docking into Flexible Active Sites. Critical Evaluation of FlexE against JNK-3 and beta-Secretase
One of the main complicating factors in structure-based drug design is the conformational rearrangement of the receptor upon… 
2002
2002
The Mechanism of γ-Secretase Activities through High Molecular Weight Complex Formation of Presenilins Is Conserved inDrosophila melanogaster and Mammals*
Mutations in presenilin 1 (PS1) and PS2 genes contribute to the pathogenesis of early onset familial Alzheimer's disease by… 
Review
2000
Review
2000
Therapeutic approaches to Alzheimer's disease.
Highly Cited
2000
Highly Cited
2000
Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design.
The final step in the generation of the amyloid-beta protein (Abeta), implicated in the etiology of Alzheimer's disease, is… 
Highly Cited
1997
Highly Cited
1997
Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases.
1994
1994
Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate
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