secretase

Known as: Amyloid Precursor Protein Secretases [Chemical/Ingredient], Amyloid Precursor Protein Secretase, Secretase, APP 
Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known… (More)
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Highly Cited
2007
Highly Cited
2007
gamma-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy… (More)
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Highly Cited
2004
Highly Cited
2004
Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and gamma-secretase to release amyloid peptides… (More)
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Highly Cited
2003
Highly Cited
2003
gamma-Secretase is a membrane protein complex with an unusual aspartyl protease activity that catalyses the regulated… (More)
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Highly Cited
2002
Highly Cited
2002
CONTEXT Amyloid plaques, a major pathological feature of Alzheimer disease (AD), are composed of an internal fragment of amyloid… (More)
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Highly Cited
2002
Highly Cited
2002
The metalloprotease ADAM 10 is an important APP alpha-secretase candidate, but in vivo proof of this is lacking. Furthermore… (More)
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Highly Cited
2001
Highly Cited
2001
Biochemical, epidemiological, and genetic findings demonstrate a link between cholesterol levels, processing of the amyloid… (More)
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Highly Cited
2000
Highly Cited
2000
Gamma-secretase-like proteolysis at site 3 (S3), within the transmembrane domain, releases the Notch intracellular domain (NICD… (More)
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Highly Cited
1999
Highly Cited
1999
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation… (More)
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Highly Cited
1999
Highly Cited
1999
Amyloid beta peptide (Abeta), the principal proteinaceous component of amyloid plaques in brains of Alzheimer's disease patients… (More)
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