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secretase

Known as: Amyloid Precursor Protein Secretases [Chemical/Ingredient], Amyloid Precursor Protein Secretase, Secretase, APP 
Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known… Expand
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Highly Cited
2007
Highly Cited
2007
γ-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy for… Expand
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Highly Cited
2006
Highly Cited
2006
Although BACE1 (beta-site amyloid precursor protein–cleaving enzyme 1) is essential for the generation of amyloid-b peptide in… Expand
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Highly Cited
2003
Highly Cited
2003
γ-Secretase catalyzes the intramembrane proteolysis of Notch, β-amyloid precursor protein, and other substrates as part of a new… Expand
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Highly Cited
2002
Highly Cited
2002
CONTEXT Amyloid plaques, a major pathological feature of Alzheimer disease (AD), are composed of an internal fragment of amyloid… Expand
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Highly Cited
2001
Highly Cited
2001
Converging lines of evidence implicate the beta‐amyloid peptide (Aβ) as causative in Alzheimer's disease. We describe a novel… Expand
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Highly Cited
2001
Highly Cited
2001
ErbB-4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding of its… Expand
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Highly Cited
2000
Highly Cited
2000
The cDNAs of two new human membrane-associated aspartic proteases, memapsin 1 and memapsin 2, have been cloned and sequenced. The… Expand
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Highly Cited
1999
Highly Cited
1999
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation… Expand
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Highly Cited
1999
Highly Cited
1999
Amyloid beta peptide (Abeta), the principal proteinaceous component of amyloid plaques in brains of Alzheimer's disease patients… Expand
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