Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease

@article{Johnston2005ExpressionAA,
  title={Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease},
  author={J. Johnston and W. W. Liu and S. Todd and D. Coulson and S. Murphy and G. B. Irvine and A. Passmore},
  journal={Biochemical Society Transactions},
  year={2005},
  volume={33},
  pages={1096-1100}
}
Several lines of evidence indicate that the Aβ peptide is involved at some level in the pathological process that results in the clinical symptoms of AD (Alzheimer9s disease). The N-terminus of Aβ is generated by cleavage of the Met-Asp bond at position 671–672 of APP (amyloid precursor protein), catalysed by a proteolytic activity called β-secretase. Two ‘β-secretase’ proteases have been identified: BACE (β-site APP-cleaving enzyme) and BACE2. The cause of sporadic AD is currently unknown, but… Expand
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