Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease

@inproceedings{Johnston2005ExpressionAA,
  title={Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease},
  author={Janet A. Johnston and Wei Wei Liu and Stephen R. Todd and David T.R. Coulson and Suzanne P. Murphy and Garry Irvine and Anthony Peter Passmore},
  year={2005}
}
Several lines of evidence indicate that the Aβ peptide is involved at some level in the pathological process that results in the clinical symptoms of AD (Alzheimer9s disease). The N-terminus of Aβ is generated by cleavage of the Met-Asp bond at position 671–672 of APP (amyloid precursor protein), catalysed by a proteolytic activity called β-secretase. Two ‘β-secretase’ proteases have been identified: BACE (β-site APP-cleaving enzyme) and BACE2. The cause of sporadic AD is currently unknown, but… CONTINUE READING

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Factors Influencing the Potency of Alzheimer Inhibitors: Computational and Docking Studies

  • American journal of Alzheimer's disease and other dementias
  • 2018
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