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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis can also cause disease. The family of cysteine proteases, theExpand
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Gene regulation and DNA damage in the ageing human brain
The ageing of the human brain is a cause of cognitive decline in the elderly and the major risk factor for Alzheimer's disease. The time in life when brain ageing begins is undefined. Here we showExpand
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Apoptosis in the nervous system
Neuronal apoptosis sculpts the developing brain and has a potentially important role in neurodegenerative diseases. The principal molecular components of the apoptosis programme in neurons includeExpand
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Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.
The amyloid beta protein is deposited in the brains of patients with Alzheimer's disease but its pathogenic role is unknown. In culture, the amyloid beta protein was neurotrophic to undifferentiatedExpand
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REST and Stress Resistance in Aging and Alzheimer’s Disease
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during ageing are unknown. Here we show that induction of theExpand
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Neural mechanisms of ageing and cognitive decline
During the past century, treatments for the diseases of youth and middle age have helped raise life expectancy significantly. However, cognitive decline has emerged as one of the greatest healthExpand
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Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
  • A. Lorenzo, B. Yankner
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 6 December 1994
beta-Amyloid (beta A) is normally produced as a nontoxic soluble peptide. In Alzheimer disease, beta A aggregates and accumulates in the brain as inert diffuse plaques or compact plaques associatedExpand
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The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
Transcriptional control of cell senescence Senescent cells that have stopped proliferating secrete molecules that influence the cells around them. Prevention of this senescence-activated secretoryExpand
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SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
Genomic instability and alterations in gene expression are hallmarks of eukaryotic aging. The yeast histone deacetylase Sir2 silences transcription and stabilizes repetitive DNA, but during aging orExpand
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Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
A formidable challenge in neural repair in the adult central nervous system (CNS) is the long distances that regenerating axons often need to travel in order to reconnect with their targets. Thus, aExpand
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