Epigenetic mechanisms of amyloid-β production in anisomycin-treated SH-SY5Y cells

@article{Guo2011EpigeneticMO,
  title={Epigenetic mechanisms of amyloid-β production in anisomycin-treated SH-SY5Y cells},
  author={Xingzhi Guo and Xingjuan Wu and Liangliang Ren and Gao-Yu Liu and Liqiong Li},
  journal={Neuroscience},
  year={2011},
  volume={194},
  pages={272-281}
}
Oxidative stress and inflammation as the pathological components of Alzheimer's disease (AD) have been well understood. Among a diversity of mitogen-activated protein kinase (MAPK) family members, JNK and p38 MAPK subfamilies are relevant to the response of environmental stress, inflammatory stimuli, or other insults. Recent studies have demonstrated that epigenetic mechanisms may play a pivotal role in AD pathogenesis and development. In the present study, we have investigated epigenetic… CONTINUE READING

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