An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
The APOE∈4 allele represents a major risk factor for AD in all ethnic groups studied, across all ages between 40 and 90 years, and in both men and women.
Neuropathological alterations in Alzheimer disease.
- A. Serrano‐Pozo, M. Frosch, E. Masliah, B. Hyman
- Biology, PsychologyCold Spring Harbor Perspectives in Medicine
- 1 September 2011
Postmortem studies have enabled the staging of the progression of both amyloid and tangle pathologies, and the development of diagnostic criteria that are now used worldwide, and these cross-sectional neuropathological data have been largely validated by longitudinal in vivo studies using modern imaging biomarkers such as amyloids PET and volumetric MRI.
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy, and after the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to the authors' surprise, NFTs continued to accumulate.
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
- T. Gómez-Isla, J. Price, Daniel W. McKeel Jr., J. Morris, J. Growdon, B. Hyman
- BiologyJournal of Neuroscience
- 15 July 1996
Stereological principles of neuron counting support the conclusion that a marked decrement of layer II neurons distinguishes even very mild AD from nondemented aging.
National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
Impairments in functional synaptic plasticity may underlie some of the cognitive deficits in these mice and, possibly, in Alzheimer's patients.
Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation
- W. Zipfel, Rebecca M. Williams, R. Christie, A. Nikitin, B. Hyman, W. Webb
- BiologyProceedings of the National Academy of Sciences…
- 19 May 2003
Applications involving a range of intrinsic molecules and molecular assemblies that enable direct visualization of tissue morphology, cell metabolism, and disease states such as Alzheimer's disease and cancer are compiled and demonstrated.
Primary age-related tauopathy (PART): a common pathology associated with human aging
A new term is recommended, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time.