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Nowcasting: the real time informational content of macroeconomic data releases
A formal method is developed for evaluating the marginal impact that intra-monthly data releases have on current-quarter forecasts (nowcasts) of real gross domestic product (GDP) growth. The method… Expand
Is the Price Level Tied to the M2 Monetary Aggregate in the Long Run
A long-run link between money and prices is evident for the United States since the Korean War if the M2 measure of money is used and the velocity of M2 (V2) is modeled as a mean-reverting series.… Expand
Regulation of APP cleavage by alpha-, beta- and gamma-secretases.
Proteolytic cleavage of the amyloid protein from the amyloid protein precursor (APP) by APP secretases is a key event in Alzheimer's disease (AD) pathogenesis. alpha-Secretases cleave APP within the… Expand
Monetary Policy When the Nominal Short-Term Interest Rate is Zero
In an environment of low inflation, the Federal Reserve faces the possibility that it may not have provided enough monetary stimulus even though it had pushed the short-term nominal interest rate to… Expand
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth
- D. Small, V. Nurcombe, +4 authors C. Masters
- Biology, Medicine
- The Journal of neuroscience : the official…
- 1 April 1994
The amyloid protein precursor (APP) of Alzheimer's disease is synthesized as an integral transmembrane protein that is released from cells in culture following proteolytic cleavage. The function of… Expand
Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease
The β‐amyloid precursor protein (APP) has been extensively studied for its role as the precursor of the β‐amyloid protein (Aβ) of Alzheimer's disease. However, the normal function of APP remains… Expand
A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.
- A. Bush, G. Multhaup, +6 authors C. Masters
- Chemistry, Medicine
- The Journal of biological chemistry
- 5 August 1993
Abnormalities of zinc metabolism occur in Alzheimer's disease (AD), a condition where pathological catabolism of the amyloid protein precursor (APP) causes cerebral beta A4 amyloidosis. An… Expand
Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.
Familial amyloidotic polyneuropathy (FAP) is an inherited autosomal dominant disease that is commonly caused by accumulation of deposits of transthyretin (TTR) amyloid around peripheral nerves. The… Expand
Regulation of APP cleavage by α‐, β‐ and γ‐secretases
Proteolytic cleavage of the amyloid protein from the amyloid protein precursor (APP) by APP secretases is a key event in Alzheimer's disease (AD) pathogenesis. α‐Secretases cleave APP within the… Expand
Revisiting the Role of Acetylcholinesterase in Alzheimer’s Disease: Cross-Talk with P-tau and β-Amyloid
- M. García-Ayllón, D. Small, Jésus Ávila, J. Sáez-Valero
- Psychology, Medicine
- Front. Mol. Neurosci.
- 27 July 2011
A common feature in the Alzheimer’s disease (AD) brain is the presence of acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and neurofibrillary tangles (NFT). Although… Expand