ertapenem

Known as: (4R,5R,6S)-3-((3S,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-yl)sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, (4R,5S,6S)-3-((3S,5S)-5-((3-Carboxyphenyl)carbamoyl)pyrrolidin-3-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid, (1R,5S,6S,8R,2'S,4's)-2-(2-(3-carboxyphenylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid 
A 1-beta-methyl carbapenem and broad-spectrum beta-lactam antibiotic with bactericidal property. Ertapenem binds to penicillin binding proteins (PBPs… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
OBJECTIVES The aim of this study was to investigate relatedness and molecular mechanism(s) of ertapenem resistance in clinical… (More)
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Review
2009
Review
2009
From early this decade, Enterobacteriaceae that produce Klebsiella pneumoniae carbapenemases (KPC) were reported in the USA and… (More)
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Highly Cited
2007
Highly Cited
2007
The emergence of carbapenem resistance in Enterobacteriaceae represents a major public health concern. We investigated ertapenem… (More)
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2007
2007
An ertapenem-resistant Escherichia coli isolate was recovered from peritoneal fluid in a patient who had been treated with… (More)
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Highly Cited
2007
Highly Cited
2007
As part of a United States-based multicenter clinical trial, conducted from 2001 to 2004, that compared ertapenem to piperacillin… (More)
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Highly Cited
2006
Highly Cited
2006
Four sequential extended-spectrum beta -lactamase-producing isolates of Klebsiella pneumoniae were obtained from a patient after… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Diabetic foot infections are a common and serious problem, yet few randomised trials of adequate quality have compared… (More)
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Highly Cited
2004
Highly Cited
2004
High-level resistance to ertapenem was produced by beta-lactamases of groups 1, 2f, and 3 in a strain of Klebsiella pneumoniae… (More)
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Review
2003
Review
2003
Ertapenem is a carbapenem that shares the activity of imipenem and meropenem against most species, but is less active against non… (More)
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2002
2002
Ertapenem (INVANZ) is a new once-a-day parenteral beta-lactam antimicrobial shown to be effective as a single agent for treatment… (More)
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