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ertapenem

Known as: (4R,5R,6S)-3-((3S,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-yl)sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, (4R,5S,6S)-3-((3S,5S)-5-((3-Carboxyphenyl)carbamoyl)pyrrolidin-3-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid, (1R,5S,6S,8R,2'S,4's)-2-(2-(3-carboxyphenylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid 
A 1-beta-methyl carbapenem and broad-spectrum beta-lactam antibiotic with bactericidal property. Ertapenem binds to penicillin binding proteins (PBPs… 
National Institutes of Health

Related topics

Related topics

22 relations
Abdominal AbscessBacterial InfectionsBacteroides InfectionsCarbapenems

Broader (2)

Anti-Bacterial Agentsbeta-Lactams

Narrower (2)

Invanzertapenem sodium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Strategies to Combat Antibiotic Resistance in the Wastewater Treatment Plants
The main goal of this manuscript is to review different treatment strategies and mechanisms for combating the antibiotic… 
Highly Cited
2016
Highly Cited
2016
Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli.
Review
2012
Review
2012
Comparative Review of the Carbapenems
The carbapenems are β-lactam antimicrobial agents with an exceptionally broad spectrum of activity. Older carbapenems, such as… 
Highly Cited
2012
Highly Cited
2012
Antimicrobial susceptibility of Enterobacteriaceae, including molecular characterization of extended-spectrum beta-lactamase-producing species, in urinary tract isolates from hospitalized patients in…
Highly Cited
2011
Highly Cited
2011
Simultaneous Determination of 12 β-Lactam Antibiotics in Human Plasma by High-Performance Liquid Chromatography with UV Detection: Application to Therapeutic Drug Monitoring
ABSTRACT A rapid and specific high-performance liquid chromatography method with UV detection (HPLC-UV) for the simultaneous… 
Highly Cited
2010
Highly Cited
2010
Analysis of 12 beta-lactam antibiotics in human plasma by HPLC with ultraviolet detection.
Highly Cited
2009
Highly Cited
2009
Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK.
OBJECTIVES The aim of this study was to investigate relatedness and molecular mechanism(s) of ertapenem resistance in clinical… 
Highly Cited
2008
Highly Cited
2008
First Report of KPC-2-Producing Klebsiella pneumoniae Strains in Brazil
The carbapenems are regarded as the preferential therapeutic option for treatment of serious health care-associated infections… 
Highly Cited
2008
Highly Cited
2008
Emergence of imipenem resistance in clinical Escherichia coli during therapy.
Review
2003
Review
2003
Ertapenem, the first of a new group of carbapenems.
β-Lactam antimicrobials have been widely prescribed to treat serious infections for nearly 60 years owing to their excellent… 
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