• Publications
  • Influence
Streptococcus pneumoniae: epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines
TLDR
Following usage of the pneumococcal conjugate vaccine in children, the incidence of invasive pneumitis disease declined in both children and adults (reflecting herd immunity), however, emergence of serotypes not encompassed in the vaccine is worrisome, and may be associated with heightened antimicrobial resistance and virulence. Expand
Fluoroquinolone-associated tendinopathy: a critical review of the literature.
TLDR
Tendon injury associated with fluoroquinolone use is significant, and risk factors such as renal disease or concurrent corticosteroid use must be considered when these agents are prescribed. Expand
The glycylcyclines: a comparative review with the tetracyclines.
TLDR
Tigecycline appears to be a promising new antibacterial based on in vitro and pharmacokinetic/pharmacodynamic activity; however more clinical data are needed to fully evaluate its potential. Expand
Clinical practice guidelines for hospital-acquired pneumonia and ventilator-associated pneumonia in adults.
TLDR
Evidence-based guidelines were prepared detailing the epidemiology, microbial etiology, risk factors and clinical manifestations of HAP and VAP and prevention and risk-reduction strategies to reduce the risk of acquiring these infections were collated. Expand
Comparative Review of the Carbapenems
TLDR
The unique antimicrobial spectrum and pharmacokinetic properties of ertapenem make it more suited to treatment of community-acquired infections and outpatient intravenous antimicrobial therapy than for the treatment of nosocomial infections. Expand
Epidemic Clonal Groups of Escherichia coli as a Cause of Antimicrobial-Resistant Urinary Tract Infections in Canada, 2002 to 2004
TLDR
Findings indicate that among the E. coli urine isolates studied, resistance to TS and FQs has a prominent clonal component, with the O15:K52:H1 clonal group and especially E. bacteria ST131 being the major contributors. Expand
Antimicrobial-Resistant Pathogens in Intensive Care Units in Canada: Results of the Canadian National Intensive Care Unit (CAN-ICU) Study, 2005-2006
TLDR
A multidrug-resistant (MDR) phenotype (resistance to three or more of the following drugs: cefepime, piperacillin-tazobactam, meropenem, amikacin or gentamicin, and ciprofloxacin) occurred frequently in P. aeruginosa but uncommonly in E. coli. Expand
Abrupt emergence of a single dominant multidrug-resistant strain of Escherichia coli.
TLDR
Most current fluoroquinolone-resistant E. coli clinical isolates represent a highly clonal subgroup that likely originated from a single rapidly expanded and disseminated ST131 strain, which expanded abruptly after 2000. Expand
Antimicrobial Resistance in Urinary Tract Pathogens in Canada from 2007 to 2009: CANWARD Surveillance Study
TLDR
It is concluded that frequently prescribed empirical agents for urinary tract infections, such as SXT and ciprofloxacin, demonstrate lowered in vitro susceptibilities when tested against recent clinical isolates. Expand
...
1
2
3
4
5
...