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Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
Summary Background Gram-negative Enterobacteriaceae with resistance to carbapenem conferred by New Delhi metallo-β-lactamase 1 (NDM-1) are potentially a major global health problem. We investigatedExpand
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beta-Lactamases in laboratory and clinical resistance.
  • D. Livermore
  • Biology, Medicine
  • Clinical microbiology reviews
  • 1 October 1995
beta-Lactamases are the commonest single cause of bacterial resistance to beta-lactam antibiotics. Numerous chromosomal and plasmid-mediated types are known and may be classified by their sequencesExpand
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Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study.
BACKGROUND Not all patients infected with NDM-1-positive bacteria have a history of hospital admission in India, and extended-spectrum β-lactamases are known to be circulating in the IndianExpand
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Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.
Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile β-lactamases have spread internationally among Gram-negative bacteria,Expand
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CTX-M: changing the face of ESBLs in Europe.
Since around 2000 - earlier in Poland and Spain and later in France and the UK - dramatic shifts have occurred in the prevalence and types of extended-spectrum beta-lactamases (ESBLs) in Europe.Expand
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The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii.
ISAba1 was found in all widespread clones of Acinetobacter baumannii in the United Kingdom. All isolates studied had a blaOXA-51-like carbapenemase gene; some also had blaOXA-23-like and/orExpand
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Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?
  • D. Livermore
  • Medicine, Biology
  • Clinical infectious diseases : an official…
  • 1 March 2002
Pseudomonas aeruginosa carries multiresistance plasmids less often than does Klebsiella pneumoniae, develops mutational resistance to cephalosporins less readily than Enterobacter species, and hasExpand
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Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp.
Carbapenem resistance in Acinetobacter baumannii is a growing public health concern and is most often mediated by OXA carbapenemases. We describe a novel multiplex polymerase chain reaction (PCR)Expand
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Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe.
Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in Europe in the 1990s, are now increasingly being identified at an alarming rate. Although their hydrolysisExpand
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Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance.
Multilocus sequence typing reveals that many bacterial species have a clonal structure and that some clones are widespread. This underlying phylogeny was not revealed by pulsed-field gelExpand
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