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Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
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beta-Lactamases in laboratory and clinical resistance
  • D. Livermore
  • Biology, Medicine
    Clinical microbiology reviews
  • 1 October 1995
TLDR
The ability of the prevalent beta-Lactamases to cause resistance to widely used beta-lactams, whether resistance is accurately reflected in routine tests, and the extent to which the antibiogram for an organism can be used to predict the type of beta- lactamase that it produces are considered.
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Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.
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Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study.
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CTX-M: changing the face of ESBLs in Europe.
TLDR
Dramatic shifts have occurred in the prevalence and types of extended-spectrum beta-lactamases (ESBLs) in Europe, and changing patterns present major therapeutic and infection control challenges, with the public health intervention points unclear.
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The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii.
TLDR
Results suggest that ISAba1 is providing the promoter for blaOXA-51-like and, probably, for blasOxA-23-like, which are likely to be the next generation of Acinetobacter baumannii isolates.
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Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?
  • D. Livermore
  • Biology
    Clinical infectious diseases : an official…
  • 1 March 2002
Pseudomonas aeruginosa carries multiresistance plasmids less often than does Klebsiella pneumoniae, develops mutational resistance to cephalosporins less readily than Enterobacter species, and has…
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Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp.
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Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe.
TLDR
Rapid identification of colonized or infected patients and screening of carriers is possible, and will probably be effective for prevention of a scenario of endemicity, as now reported for extended-spectrum β-lactamase producers in all European countries.
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Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance.
TLDR
'high-risk clones' play a major role in the spread of resistance, with the risk lying in their tenacity--deriving from poorly understood survival traits--and a flexible ability to accumulate and switch resistance, rather than to constant resistance batteries.
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