beta-Lactams

Known as: beta-Lactams [Chemical/Ingredient], beta Lactams, Beta-lactam 
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo… (More)
National Institutes of Health

Related topics

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18 relations

Broader (2)

Anti-Bacterial AgentsLactams

Narrower (9)

CA-104Disodium LatamoxefRX-10100T 5575
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In BloodPoisoning by cefalosporins and other beta-lactam antibioticsagonistsantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Extended-spectrum beta-lactamases: a clinical update.
Extended-spectrum beta-lactamases (ESBLs) are a rapidly evolving group of beta-lactamases which share the ability to hydrolyze… (More)
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Review
2005
Review
2005
Metallo-beta-lactamases: the quiet before the storm?
The ascendancy of metallo-beta-lactamases within the clinical sector, while not ubiquitous, has nonetheless been dramatic; some… (More)
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Highly Cited
2004
Highly Cited
2004
SOS response induction by beta-lactams and bacterial defense against antibiotic lethality.
The SOS response aids bacterial propagation by inhibiting cell division during repair of DNA damage. We report that inactivation… (More)
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Review
2003
Review
2003
Basic pharmacodynamics of antibacterials with clinical applications to the use of beta-lactams, glycopeptides, and linezolid.
Time above MIC for free drug concentrations is the important PK-PD parameter correlating with the efficacy of beta-lactam… (More)
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Review
2001
Review
2001
Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.
Beta-lactamases continue to be the leading cause of resistance to beta-lactam antibiotics among gram-negative bacteria. In recent… (More)
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Highly Cited
2001
Highly Cited
2001
Mechanism of synergy between epigallocatechin gallate and beta-lactams against methicillin-resistant Staphylococcus aureus.
Compared to MICs (more than 800 microg/ml) of (-)-epigallocatechin gallate (EGCg) against Escherchia coli, MICs of EGCg against… (More)
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Review
1998
Review
1998
The pharmacodynamics of beta-lactams.
Considerable information on the pharmacodynamics of beta-lactams has accumulated in the past 20 years. In vitro, beta-lactams… (More)
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Highly Cited
1988
Highly Cited
1988
Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns.
Before 1985 at the Pitié-Salpêtrière Hospital in Paris (2,400 beds), resistance to cefotaxime in clinical isolates of… (More)
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Highly Cited
1980
Highly Cited
1980
The structure of beta-lactamases.
The beta-lactamases are widely distributed in both Gram-positive and Gram-negative bacteria. They all inactivate penicillins and… (More)
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Highly Cited
1972
Highly Cited
1972
Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.
A new cephalosporin with a highly reactive beta-lactam ring was found to give an immediate color change in the presence of beta… (More)
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