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Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
TLDR
The prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in India, Pakistan, and the UK is investigated, and co-ordinated international surveillance is needed. Expand
Vancomycin-resistant enterococci
TLDR
It is proposed that a fundamental difference may be that with viscoelastic hydrodissection, the endothelial cells still function and will eventually reattach without surgical intervention, and both cases attained good vision, although their case had fluid air exchange at six weeks. Expand
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.
TLDR
The epidemiology of Klebsiella pneumoniae carbapenemases across continents is summarized, issues around detection, present antibiotic options and those in development, treatment outcome and mortality, and infection control are discussed. Expand
CTX-M: changing the face of ESBLs in Europe.
TLDR
Dramatic shifts have occurred in the prevalence and types of extended-spectrum beta-lactamases (ESBLs) in Europe, and changing patterns present major therapeutic and infection control challenges, with the public health intervention points unclear. Expand
The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii.
TLDR
Results suggest that ISAba1 is providing the promoter for blaOXA-51-like and, probably, for blasOxA-23-like, which are likely to be the next generation of Acinetobacter baumannii isolates. Expand
Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe.
TLDR
Rapid identification of colonized or infected patients and screening of carriers is possible, and will probably be effective for prevention of a scenario of endemicity, as now reported for extended-spectrum β-lactamase producers in all European countries. Expand
Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp.
TLDR
A novel multiplex polymerase chain reaction (PCR) assay able to detect and distinguish alleles encoding three subgroups of acquired OXA carbapenemases that are scattered in Acinetobacter spp. Expand
Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance.
TLDR
'high-risk clones' play a major role in the spread of resistance, with the risk lying in their tenacity--deriving from poorly understood survival traits--and a flexible ability to accumulate and switch resistance, rather than to constant resistance batteries. Expand
Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum beta-lactamases in the UK.
TLDR
Because of the public health implications, including for the treatment of community-acquired urinary tract infections, the spread of these strains--and CTX-M-15 beta-lactamase in particular--merits close monitoring. Expand
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