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Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
Summary Background Gram-negative Enterobacteriaceae with resistance to carbapenem conferred by New Delhi metallo-β-lactamase 1 (NDM-1) are potentially a major global health problem. We investigatedExpand
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Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.
Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile β-lactamases have spread internationally among Gram-negative bacteria,Expand
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CTX-M: changing the face of ESBLs in Europe.
Since around 2000 - earlier in Poland and Spain and later in France and the UK - dramatic shifts have occurred in the prevalence and types of extended-spectrum beta-lactamases (ESBLs) in Europe.Expand
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Vancomycin-resistant enterococci
against stroma. The free edge of the detachment was sutured with two 10-0 nylon sutures at the superotemporal incision. Visual acuity improved to 20/70 with less cornea edema, and some areas of theExpand
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The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii.
ISAba1 was found in all widespread clones of Acinetobacter baumannii in the United Kingdom. All isolates studied had a blaOXA-51-like carbapenemase gene; some also had blaOXA-23-like and/orExpand
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Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp.
Carbapenem resistance in Acinetobacter baumannii is a growing public health concern and is most often mediated by OXA carbapenemases. We describe a novel multiplex polymerase chain reaction (PCR)Expand
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Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe.
Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in Europe in the 1990s, are now increasingly being identified at an alarming rate. Although their hydrolysisExpand
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Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum (beta)-lactamases.
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Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance.
Multilocus sequence typing reveals that many bacterial species have a clonal structure and that some clones are widespread. This underlying phylogeny was not revealed by pulsed-field gelExpand
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Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum beta-lactamases in the UK.
OBJECTIVES During 2003, the Health Protection Agency's Antibiotic Resistance Monitoring and Reference Laboratory began to receive isolates of Escherichia coli for confirmation of extended-spectrumExpand
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