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Global Spread of Carbapenemase-producing Enterobacteriaceae
These resistance traits have been identified among nosocomial and community-acquired infections and are being investigated for use in drug discovery and development.
OXA-48-like carbapenemases: the phantom menace.
Since many OXA-48-like producers do not exhibit resistance to broad-spectrum cephalosporins, or only decreased susceptibility to carbapenems, their recognition and detection can be challenging.
Metallo-β-Lactamases: the Quiet before the Storm?
Their rapid dissemination is worrisome and necessitates the implementation of not just surveillance studies but also metallo-β-lactamase inhibitor studies securing the longevity of important anti-infectives.
Comparative Genomics of Multidrug Resistance in Acinetobacter baumannii
Acinetobacter baumannii is a species of nonfermentative gram-negative bacteria commonly found in water and soil. This organism was susceptible to most antibiotics in the 1970s. It has now become a…
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.
Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology.
In addition to beta-lactamases, carbapenem resistance in A. baumannii may also result from porin or penicillin-binding protein modifications, and several porins, including the 33-kDa CarO protein, that constitute a pore channel for influx ofcarbapenems, might be involved in carbapanem resistance.
Emergence of Oxacillinase-Mediated Resistance to Imipenem in Klebsiella pneumoniae
- L. Poirel, C. Héritier, Venus Tolün, P. Nordmann
- BiologyAntimicrobial Agents and Chemotherapy
- 1 January 2004
The high-level resistance to β-lactams of this clinical isolate resulted from peculiar β- lactamases and modification of outer membrane proteins.
Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes
Genotypic and phenotypic methods that provide relevant information for diagnostic laboratories are presented and recent works in relation to recently identified mechanisms of polymyxin resistance, including chromosomally encoded resistance traits as well as the recently identified plasmid-encoded polymyXin resistance determinant MCR-1 are presented.
CTX-M: changing the face of ESBLs in Europe.
- D. Livermore, R. Cantón, N. Woodford
- Medicine, BiologyJournal of Antimicrobial Chemotherapy
- 6 December 2006
Dramatic shifts have occurred in the prevalence and types of extended-spectrum beta-lactamases (ESBLs) in Europe, and changing patterns present major therapeutic and infection control challenges, with the public health intervention points unclear.
Metallo-beta-lactamases: the quiet before the storm?
Their rapid dissemination is worrisome and necessitates the implementation of not just surveillance studies but also metallo-beta-lactamase inhibitor studies securing the longevity of important anti-infectives.