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Global Spread of Carbapenemase-producing Enterobacteriaceae
TLDR
These resistance traits have been identified among nosocomial and community-acquired infections and are being investigated for use in drug discovery and development. Expand
Metallo-β-Lactamases: the Quiet before the Storm?
TLDR
Their rapid dissemination is worrisome and necessitates the implementation of not just surveillance studies but also metallo-β-lactamase inhibitor studies securing the longevity of important anti-infectives. Expand
Comparative Genomics of Multidrug Resistance in Acinetobacter baumannii
Acinetobacter baumannii is a species of nonfermentative gram-negative bacteria commonly found in water and soil. This organism was susceptible to most antibiotics in the 1970s. It has now become aExpand
Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology.
TLDR
In addition to beta-lactamases, carbapenem resistance in A. baumannii may also result from porin or penicillin-binding protein modifications, and several porins, including the 33-kDa CarO protein, that constitute a pore channel for influx ofcarbapenems, might be involved in carbapanem resistance. Expand
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.
TLDR
The epidemiology of Klebsiella pneumoniae carbapenemases across continents is summarized, issues around detection, present antibiotic options and those in development, treatment outcome and mortality, and infection control are discussed. Expand
OXA-48-like carbapenemases: the phantom menace.
TLDR
Since many OXA-48-like producers do not exhibit resistance to broad-spectrum cephalosporins, or only decreased susceptibility to carbapenems, their recognition and detection can be challenging. Expand
Emergence of Oxacillinase-Mediated Resistance to Imipenem in Klebsiella pneumoniae
TLDR
The high-level resistance to β-lactams of this clinical isolate resulted from peculiar β- lactamases and modification of outer membrane proteins. Expand
Metallo-beta-lactamases: the quiet before the storm?
TLDR
Their rapid dissemination is worrisome and necessitates the implementation of not just surveillance studies but also metallo-beta-lactamase inhibitor studies securing the longevity of important anti-infectives. Expand
CTX-M: changing the face of ESBLs in Europe.
TLDR
Dramatic shifts have occurred in the prevalence and types of extended-spectrum beta-lactamases (ESBLs) in Europe, and changing patterns present major therapeutic and infection control challenges, with the public health intervention points unclear. Expand
The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide.
TLDR
Control of the spread of carbapenemase producers in Enterobacteriaceae is still possible in hospital settings, and relies on the use of rapid diagnostic techniques and the strict implemention of hygiene measures. Expand
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