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elsamicin A

Known as: Benzo(h)(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,12-dione, 10-((2-O-(2-amino-2,6-dideoxy-3-O-methyl-alpha-D-galactopyranosyl)-6-deoxy-3-C-methyl-beta-D-galactopyranosyl)oxy)-6-hydroxy-1-methyl-, 10-O-Elsaminosylelsarosylchartarin, Benzo(h)(1)benzopyrano(5,4,3-cde)(1)ebnzopyran-5,12-dione,10((2-O-(2-amino-2,6-dideoxy-3-O-methyl-alpha-D-galactopyranosyl)-6-deoxy-3-C-methyl-beta-D-galactopyranosyl)oxy)-6-hydroxy-1-methyl 
An heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

AminoglycosidesAntibiotics, Antineoplastic

Narrower (2)

BBM 2478ABMY 28090

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities.
Natural products of the benzonaphthopyranone class, such as chartreusin, elsamicin A, gilvocarcin, and polycarcin, represent… 
2004
2004
Phase II study of elsamitrucin in non-small cell lung cancer
Elsamitrucin (BMY-28090) a novel fermentation product has demonstrated pre-clinical anti-tumour activity against a number of cell… 
1999
1999
Safety and efficacy of using a single agent or a phase II agent before instituting standard combination chemotherapy in previously untreated metastatic breast cancer patients: report of a randomized…
PURPOSE We undertook a prospective, randomized phase III trial to evaluate the safety and efficacy of using a phase II agent… 
1996
1996
Influence of elsamicin A on the activity of mammalian topoisomerase I.
The strong effect of elsamicin A on the mobility of DNA in agarose gels has been characterized. This antibiotic forms tight… 
1995
1995
Molecular dynamics study of the binding of elsamicin A to DNA.
Molecular mechanics (MM) and dynamics (MD) were used to examine the conformational flexibility of elsamicin A, an antitumour… 
1995
1995
Abortive transcription of the T7 promoter induced by elsamicin A.
The capacity of two intercalating drugs, actinomycin D and elsamicin A, to act as obstacles to transcript elongation by T7 RNA… 
1992
1992
Phase I trial and clinical pharmacology of elsamitrucin.
Elsamitrucin (BMY-28090) is an antitumor antibiotic first described in 1985 that has significant oncolytic activity against a… 
1992
1992
Experimental and modelling studies on the DNA cleavage by elsamicin A.
The ability of elsamicin A, an antitumour antibiotic, to cleave DNA in the presence of ferrous iron and reducing agents, has been… 
1991
1991
Selective DNA cleavage by elsamicin A and switch function of its amino sugar group.
We report guanine-specific recognition and selective cleavage of DNA by the antitumor antibiotic elsamicin A equipped with an… 
1989
1989
Biosynthesis of elsamicin A, a novel antitumor antibiotic.
The 1H noise-decoupled 13C-nmr spectrum of elsamicin A [1] prepared from the cultures of an unknown actinomycete species (ATCC… 
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