Corpus ID: 9854986

Phase I trial and clinical pharmacology of elsamitrucin.

  title={Phase I trial and clinical pharmacology of elsamitrucin.},
  author={M. Raber and R. Newman and B. Newman and R. Gaver and L. Schacter},
  journal={Cancer research},
  volume={52 6},
Elsamitrucin (BMY-28090) is an antitumor antibiotic first described in 1985 that has significant oncolytic activity against a number of murine tumors including P388, L1210, B16 and M5076, as well as against MX1 and HCT116 xenografts. Preclinical toxicology studies of elsamitrucin revealed edema of multiple organs associated with hypoproteinemia and, at lethal doses, severe multiorgan toxicity. We conducted a phase I clinical trial (31 patients) of elsamitrucin administered as a 10-min i.v… Expand
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