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A phase II study of recombinant tumor necrosis factor in renal cell carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group.
TLDR
It is concluded that rTNF, given as described, has only modest antitumor activity in renal cell carcinoma and produces considerable toxicity.
Interleukin 1 enhances growth factor-dependent proliferation of the clonogenic cells in acute myeloblastic leukemia and of normal human primitive hemopoietic precursors
TLDR
It is reported that rIL-1 acts synergistically with granulocyte/macrophage CSF (GM- CSF) orgranulocyte CSF in the stimulation of clonogenic cells from many patients with acute myeloblastic leukemia (AML).
Allogeneic transplantation for multiple myeloma: further evidence for a GVHD-associated graft-versus-myeloma effect
TLDR
It is confirmed that early allografting in MM can yield toxicity rates significantly lower than those associated with historical cohorts, and the hypothesis that cumulative chemotoxicity has a negative influence on mortality and survival rates is supported.
Docetaxel in patients with metastatic breast cancer: a phase II study of the National Cancer Institute of Canada-Clinical Trials Group.
TLDR
Docetaxel is an active agent in MBC and its activity as a single agent is comparable to many combination chemotherapy regimens and is not affected by prior adjuvant chemotherapy.
A large multisite cancer family is linked to BRCA2.
TLDR
A large French-Canadian family with 21 cases of breast cancer, including two affected brothers, showed linkage to the BRCA2 gene locus and a number of cancers of other types occurred in this family.
Acute and delayed emesis after cisplatin-based regimen: description and prevention.
Lorazepam, dexamethasone and high-dose metoclopramide were given to 54 patients to prevent emesis induced by cisplatin (50-120 mg/m2) on day 1, while prochlorperazine and dexamethasone were
Coordinate secretion of interleukin-1 beta and granulocyte-macrophage colony-stimulating factor by the blast cells of acute myeloblastic leukemia: role of interleukin-1 as an endogenous inducer.
TLDR
The results are consistent with the view that the production of IL-1 beta by AML blasts supports autocrine growth in culture, through induction of CSFs or other cytokines that stimulate blast proliferation.
Implementing DPYD*2A genotyping in clinical practice: The Quebec (Canada) experience.
TLDR
It is demonstrated that upfront genotyping of DPYD before fluoropyrimidine-based treatment is feasible in clinical practice and can prevent severe toxicities and hospitalizations without delaying treatment initiation.
Phase II study of elsamitrucin in non-small cell lung cancer
TLDR
The results indicate that elsamitrucin when given in this dose and schedule to patients with surgically incurable non-small cell lung cancer has no activity.
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