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A phase II study of recombinant tumor necrosis factor in renal cell carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group.
- J. Skillings, R. Wierzbicki, B. Weinerman
- MedicineJournal of immunotherapy : official journal of…
It is concluded that rTNF, given as described, has only modest antitumor activity in renal cell carcinoma and produces considerable toxicity.
Interleukin 1 enhances growth factor-dependent proliferation of the clonogenic cells in acute myeloblastic leukemia and of normal human primitive hemopoietic precursors
It is reported that rIL-1 acts synergistically with granulocyte/macrophage CSF (GM- CSF) orgranulocyte CSF in the stimulation of clonogenic cells from many patients with acute myeloblastic leukemia (AML).
Allogeneic transplantation for multiple myeloma: further evidence for a GVHD-associated graft-versus-myeloma effect
It is confirmed that early allografting in MM can yield toxicity rates significantly lower than those associated with historical cohorts, and the hypothesis that cumulative chemotoxicity has a negative influence on mortality and survival rates is supported.
Docetaxel in patients with metastatic breast cancer: a phase II study of the National Cancer Institute of Canada-Clinical Trials Group.
- M. Trudeau, E. Eisenhauer, A. Muldal
- MedicineJournal of clinical oncology : official journal…
- 1 February 1996
Docetaxel is an active agent in MBC and its activity as a single agent is comparable to many combination chemotherapy regimens and is not affected by prior adjuvant chemotherapy.
A large multisite cancer family is linked to BRCA2.
A large French-Canadian family with 21 cases of breast cancer, including two affected brothers, showed linkage to the BRCA2 gene locus and a number of cancers of other types occurred in this family.
Acute and delayed emesis after cisplatin-based regimen: description and prevention.
Lorazepam, dexamethasone and high-dose metoclopramide were given to 54 patients to prevent emesis induced by cisplatin (50-120 mg/m2) on day 1, while prochlorperazine and dexamethasone were…
Coordinate secretion of interleukin-1 beta and granulocyte-macrophage colony-stimulating factor by the blast cells of acute myeloblastic leukemia: role of interleukin-1 as an endogenous inducer.
- J. C. Rodriguez‐Cimadevilla, V. Beauchemin, L. Villeneuve, F. Letendre, A. Shaw, T. Hoang
- 15 October 1990
The results are consistent with the view that the production of IL-1 beta by AML blasts supports autocrine growth in culture, through induction of CSFs or other cytokines that stimulate blast proliferation.
Hereditary breast cancer in 19 females and 2 males: Kindred, P.G. 1940.
Implementing DPYD*2A genotyping in clinical practice: The Quebec (Canada) experience.
It is demonstrated that upfront genotyping of DPYD before fluoropyrimidine-based treatment is feasible in clinical practice and can prevent severe toxicities and hospitalizations without delaying treatment initiation.
Phase II study of elsamitrucin in non-small cell lung cancer
The results indicate that elsamitrucin when given in this dose and schedule to patients with surgically incurable non-small cell lung cancer has no activity.