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The biosynthetic logic of polyketide diversity.
This review highlights recently unveiled biosynthetic mechanisms to generate highly diverse and complex molecules that lead to the large structural diversity of polyketides.
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The
Intimate bacterial–fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans
Results provide evidence of specific interaction among microorganisms belonging to different domains and support the hypothesis that not only diffusible signals but intimate physical interactions contribute to the communication among micro organisms and induction of otherwise silent biosynthesis genes.
Pathogenic fungus harbours endosymbiotic bacteria for toxin production
It is shown that rhizoxin is not biosynthesized by the fungus itself, but by endosymbiotic, that is, intracellular living, bacteria of the genus Burkholderia, which extends the fungus–plant interaction to a third, bacterial, key-player, and opens new perspectives for pest control.
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.
This review covers advances in understanding of the biosynthesis of polyketides produced by type II PKS systems at the genetic, biochemical and structural levels.
Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans.
A new strategy is reported for the successful induction of a silent metabolic pathway in the important model organism Aspergillus nidulans, which led to the discovery of novel PKS-NRPS hybrid metabolites.
Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection
It is shown that trans-AT PKSs evolved in a fundamentally different fashion from cis-AT systems, through horizontal recruitment and assembly of substrate-specific ketosynthase (KS) domains, and will facilitate both the discovery of novel polyketides by genome mining and the extraction of chemical information from short trans- AT PCR products, using metagenomic DNA of marine sponges.
Minimum Information about a Biosynthetic Gene cluster.
This work proposes the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard, to facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters.