• Publications
  • Influence
[In-vivo activation of the p53 pathway by small-molecule antagonists of MDM2].
  • T. Shinohara, M. Uesugi
  • Medicine, Biology
  • Tanpakushitsu kakusan koso. Protein, nucleic acid…
  • 1 October 2007
Induced alpha helix in the VP16 activation domain upon binding to a human TAF.
TLDR
Identification of the two hydrophobic residues that make nonpolar contacts suggests a general recognition motif of acidic activation domains for hTAFII31, a human TFIID TATA box-binding protein-associated factor. Expand
[Discovering high-affinity ligands for proteins: SAR by NMR].
  • S. Kamisuki, M. Uesugi
  • Biology, Medicine
  • Tanpakushitsu kakusan koso. Protein, nucleic acid…
  • 1 October 2007
Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF
TLDR
Identification of the two hydrophobic residues that make nonpolar contacts suggests a general recognition motif of acidic activation domains for hTAFII31, a human TFIID TATA box – binding protein-associated factor. Expand
Differential Association of Products of Alternative Transcripts of the Candidate Tumor Suppressor ING1 with the mSin3/HDAC1 Transcriptional Corepressor Complex*
  • D. Skowyra, M. Zeremski, +7 authors Jun Qin
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 23 March 2001
The candidate tumor suppressor ING1was identified in a genetic screen aimed at isolation of human genes whose expression is suppressed in cancer cells. It may function as a negative growth regulatorExpand
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.
TLDR
Combined use of KY02111 and WNT signaling modulators produced robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin. Expand
A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.
TLDR
The analysis suggests that fatostatin inhibits the ER-Golgi translocation of SREBPs through binding to their escort protein, the SREBP cleavage-activating protein (SCAP), at a distinct site from the sterol-binding domain. Expand
A second calcineurin binding site on the NFAT regulatory domain.
TLDR
The identification of a second Cn-binding element in NFATc, which synergizes with the previously identified element and is found that the two sites contribute differentially to the overall affinity for Cn in an isoform-dependent manner. Expand
Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin.
TLDR
The results indicate that insertion of a long, rigid polyproline helix between a small-molecule bait and a biotin tag boosts the capacity of affinity purification and thereby permits isolation of low-abundance or low-affinity proteins. Expand
Divergent hTAFII31-binding Motifs Hidden in Activation Domains* 210
TLDR
This work delineates the peptide sequences that are required for transactivation and interaction with hTAFII31, a classical target of the acidic class of activation domains, and indicates that hTAfII31 recognizes a diverse set of sequences for trans activation. Expand
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