edelfosine

Known as: Edelfosinum, ET-18-O-methyl, 1-octadecyl-2-methylglycero-3-phosphocholine 
A synthetic analog of lysophosphatidylcholine, an ether lipid, possessing anti-leishmanial and antineoplastic activity. The mechanism of action for… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2018
010203019802018

Papers overview

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2015
2015
BACKGROUND/AIMS The anti-inflammatory, anti-autoimmune, antiparasitic, and anti-viral ether phospholipid edelfosine (1-O… (More)
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Highly Cited
2010
Highly Cited
2010
Leptin can exert its potent appetite-suppressing effects via activation of hypothalamic proopiomelanocortin (POMC) neurons. It… (More)
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Highly Cited
2007
Highly Cited
2007
Multiple myeloma (MM) is an incurable B-cell malignancy, requiring new therapeutic strategies. We have found that synthetic alkyl… (More)
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Highly Cited
2005
Highly Cited
2005
Central nervous system responses to cannabis are primarily mediated by CB(1) receptors, which couple preferentially to G(i/o) G… (More)
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2003
2003
The alkylphosphocholine class of drugs, including edelfosine and miltefosine, has recently shown promise in the treatment of… (More)
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Highly Cited
2003
Highly Cited
2003
Nicotine is not only a major component in tobacco but is also a survival agonist that inhibits apoptosis induced by diverse… (More)
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Highly Cited
2002
Highly Cited
2002
The sensitivities of both promastigote and amastigote stages of six species of Leishmania, L. donovani, L. major, L. tropica, L… (More)
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Highly Cited
1997
Highly Cited
1997
The ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3; Edelfosine) has been shown to be a rapid… (More)
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Highly Cited
1992
Highly Cited
1992
The ether lipid analogue 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) has been shown to be a direct inhibitor… (More)
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Highly Cited
1990
Highly Cited
1990
The influence of cholesterol on the phase behavior of glycerophospholipids and sphingomyelins was investigated by spin-label… (More)
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