Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat.
Effect of Chemokine Receptors CXCR4 and CCR7 on the Metastatic Behavior of Human Colorectal Cancer
Strong expression of CXCR4 by colorectal cancer cells is significantly associated with lymphatic and distant dissemination in patients with coloreCTal cancer as well as with cancer cell migration in vitro.
High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells.
AIM To analyze the relevance of the microRNA miR-196a for colorectal oncogenesis. METHODS The impact of miR-196a on the restriction targets HoxA7, HoxB8, HoxC8 and HoxD8 was analyzed by reverse…
Identification and characterization of riproximin, a new type II ribosome‐inactivating protein with antineoplastic activity from Ximenia americana
Sequence analysis and molecular modeling showed that the new protein, riproximin, belongs to the family of type II ribosome inactivating proteins, and suggests that riproxIMin has distinct potential for cancer treatment.
Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer
Evaluated tumour tissues from 94 patients undergoing surgery for colorectal cancer for loss of Hugl-1 transcription and compared these findings with the clinical data from each of these patients found that HugL-1 was lost in 75% of tumours and these losses were associated with advanced stage and particularly with lymph node metastases.
Osteonectin Influences Growth and Invasion of Pancreatic Cancer Cells
In vitro studies showed that osteonectin was able to inhibit cancer cell growth while promoting invasiveness of pancreatic tumor cells, and is markedly overexpressed in pancreatic cancer and has the potential to increase the invAsiveness of Pancreatic cancer cells.
Plant ribosome-inactivating proteins type II induce the unfolded protein response in human cancer cells
- C. Horrix, Z. Raviv, E. Flescher, C. Voss, M. Berger
- Biology, ChemistryCellular and Molecular Life Sciences
- 1 April 2011
The unfolded protein response (UPR), a cellular mechanism activated in response to endoplasmic reticulum stress, that is induced in HCT116 and MDA-MB-231 cells exposed to plant type II RIPs ricin, riproximin and volkensin is identified.
Combination experiments with very low doses of three genotoxic N-nitrosamines with similar organotropic carcinogenicity in rats.
The results indicate dose dependency of liver tumor formation even at very low exposure levels of the individual agents, and the carcinogenic effects of the hepatotropic N-nitrosamines summed up in combination.
Lifelong exposure to di-(2-ethylhexyl)-phthalate induces tumors in liver and testes of Sprague-Dawley rats.
Osteopontin influences the invasiveness of pancreatic cancer cells and is increased in neoplastic and inflammatory conditions
The results do suggest, however, that blockade of OPN might be useful as a therapeutic approach to inhibit invasion and metastasis of pancreatic cancer cells.