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DIET AND cancer.
In the authors' opinion the scientific basis for recommendations seems to be too small to justify very restrictive diets for cancer prevention and recommendations favoring certain diets should be given with all due caution. Expand
Syncarcinogenic action of polycyclic hydrocarbons in automobile exhaust gas condensates.
The carcinogenic action of the hydrocarbon mixture predominantly found in condensates of automobile exhaust gas can be attributed almost exclusively, on the basis of the results presented here, to aExpand
Investigation of the tumorigenic response to benzo(a)pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats
The 1.5% caffeine solution (annual dose 27 g/kg) did not exert any carcinogenic activity under the conditions of this bioassay. Expand
Carcinogenic action of low‐dose cyclophosphamide given orally to sprague‐dawley rats in a lifetime experiment
Findings support the evidence emerging from case reports in humans showing an increased risk of cancer of the urinary bladder as well as of leukemia in patients treated with CP. Expand
Combination experiments with very low doses of three genotoxic N-nitrosamines with similar organotropic carcinogenicity in rats.
The results indicate dose dependency of liver tumor formation even at very low exposure levels of the individual agents, and the carcinogenic effects of the hepatotropic N-nitrosamines summed up in combination. Expand
New cytostatics with experimentally different toxic profiles.
The methylnitrosourea-induced autochthonous mammary carcinoma has been found to be a reliable and valid model in the selection of active compounds of this class of agents and an alkylphosphocholine (HPC) was used as 'negative control' which had the highest antineoplastic activity of the whole series against MNU-induced rat mammary cancer. Expand
Carcinogenicity of acetoxymethyl-methyl-nitrosamine after subcutaneous, intravenous and intrarectal applications in rats
The lung and heart, and to a less extent the kidney and earduct were found as target organs of distant carcinogenic response in male Sprague-Dawley or Wistar rats. Expand
Carcinogenicity of N-nitrosodiethanolamine in rats at five different dose levels.
It is proposed that an as yet unidentified metabolite may possess high carcinogenic potential in male Sprague-Dawley rats, and even low doses of N-nitrosodiethanolamine are carcinogenic. Expand
Noncarcinogenic chemotherapy with a combination of vincristine, methotrexate and 5‐fluorouracil (VMF) in rats
The present therapy did not result in an increased tumor rate or a change in tumor type over controls, indicating a possible superiority of VMF over CMF, since the former exhibits little or no carcinogenicity at comparable therapeutic activity. Expand
Occurrence of second primary malignancies in man--a second look.