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Phosphodiesterase Inhibitors

Known as: PDE Inhibitor, Phosphodiesterase Inhibitor, Phosphoric Diester Hydrolase Inhibitors 
Any substance that inhibits phosphodiesterase, an enzyme that catalyzes the breaking of a phosphodiester bond. Usually, this refers to cyclic… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
OBJECTIVE Recent studies have demonstrated that hydrogen sulfide (H(2)S) is produced within the vessel wall from L-cysteine… Expand
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Review
2005
Review
2005
Inhibitors of phosphodiesterase type 4 (PDE4) act by increasing intracellular concentrations of cyclic AMP, which has a broad… Expand
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Highly Cited
2005
Highly Cited
2005
Increased oxidative stress has been suggested to be involved in the pathogenesis and progression of diabetic tissue damage. The… Expand
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Highly Cited
2004
Highly Cited
2004
Although there is no spontaneous regeneration of mammalian spinal axons after injury, they can be enticed to grow if cAMP is… Expand
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Highly Cited
2004
Highly Cited
2004
The phosphodiesterase inhibitor, ibudilast, has many effects on lymphocytes, endothelial cells, and glial cells. We examined the… Expand
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Highly Cited
2003
Highly Cited
2003
Inducible nitric oxide synthase (iNOS) is expressed in both the fibrotic plaque of Peyronie's disease (PD) in the human, and in… Expand
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Highly Cited
1998
Highly Cited
1998
In an attempt to improve behavioral memory, we devised a strategy to amplify the signal-to-noise ratio of the cAMP pathway, which… Expand
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Highly Cited
1996
Highly Cited
1996
Sildenafil (Viagra, UK-92,480) is a novel oral agent under development for the treatment of penile erectile dysfunction. Erection… Expand
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Highly Cited
1992
Highly Cited
1992
The psychoactive properties of Cannabis sativa and its major biologically active constituent, delta 9-tetrahydrocannabinol, have… Expand
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Highly Cited
1991
Highly Cited
1991
BACKGROUND Milrinone, a phosphodiesterase inhibitor, enhances cardiac contractility by increasing intracellular levels of cyclic… Expand
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