Phosphodiesterase Inhibitors

Known as: PDE Inhibitor, Phosphodiesterase Inhibitor, Phosphoric Diester Hydrolase Inhibitors 
Any substance that inhibits phosphodiesterase, an enzyme that catalyzes the breaking of a phosphodiester bond. Usually, this refers to cyclic… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2018
05010015019672018

Papers overview

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Highly Cited
2010
Highly Cited
2010
OBJECTIVE Recent studies have demonstrated that hydrogen sulfide (H(2)S) is produced within the vessel wall from L-cysteine… (More)
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Highly Cited
2005
Highly Cited
2005
Incubation of purified C57BL/6 murine CD4(+) T lymphocytes with anti-CD3 mAb serves as a model of TCR-mediated activation and… (More)
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Highly Cited
2004
Highly Cited
2004
Although there is no spontaneous regeneration of mammalian spinal axons after injury, they can be enticed to grow if cAMP is… (More)
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Highly Cited
2000
Highly Cited
2000
The specific type IV phosphodiesterase inhibitor rolipram is a potent suppressor of tumor necrosis factor-alpha (TNF) synthesis… (More)
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Highly Cited
2000
Highly Cited
2000
OBJECTIVES To determine the acute effects of type 5 phosphodiesterase inhibition with sildenafil on flow-mediated vasodilation in… (More)
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Highly Cited
1998
Highly Cited
1998
In an attempt to improve behavioral memory, we devised a strategy to amplify the signal-to-noise ratio of the cAMP pathway, which… (More)
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Highly Cited
1998
Highly Cited
1998
Cyclic nucleotide phosphodiesterases (PDEs) regulate intracellular levels of cAMP and cGMP by hydrolyzing them to their… (More)
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Highly Cited
1996
Highly Cited
1996
Sildenafil (Viagra, UK-92,480) is a novel oral agent under development for the treatment of penile erectile dysfunction. Erection… (More)
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Highly Cited
1992
Highly Cited
1992
The psychoactive properties of Cannabis sativa and its major biologically active constituent, delta 9-tetrahydrocannabinol, have… (More)
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Highly Cited
1991
Highly Cited
1991
BACKGROUND Milrinone, a phosphodiesterase inhibitor, enhances cardiac contractility by increasing intracellular levels of cyclic… (More)
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