Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Phosphodiesterase Inhibitors

Known as: PDE Inhibitor, Phosphodiesterase Inhibitor, Phosphoric Diester Hydrolase Inhibitors 
Any substance that inhibits phosphodiesterase, an enzyme that catalyzes the breaking of a phosphodiester bond. Usually, this refers to cyclic… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Objective—Recent studies have demonstrated that hydrogen sulfide (H2S) is produced within the vessel wall from l-cysteine… Expand
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Review
2005
Review
2005
Inhibitors of phosphodiesterase type 4 (PDE4) act by increasing intracellular concentrations of cyclic AMP, which has a broad… Expand
Highly Cited
2004
Highly Cited
2004
Although there is no spontaneous regeneration of mammalian spinal axons after injury, they can be enticed to grow if cAMP is… Expand
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • figure 5
Highly Cited
2003
Highly Cited
2003
Inducible nitric oxide synthase (iNOS) is expressed in both the fibrotic plaque of Peyronie's disease (PD) in the human, and in… Expand
Review
2000
Review
2000
Drug interactions occur when the efficacy or toxicity of a medication is changed by administration of another substance… Expand
Highly Cited
1998
Highly Cited
1998
In an attempt to improve behavioral memory, we devised a strategy to amplify the signal-to-noise ratio of the cAMP pathway, which… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Highly Cited
1996
Highly Cited
1996
Sildenafil (Viagra, UK-92,480) is a novel oral agent under development for the treatment of penile erectile dysfunction. Erection… Expand
Highly Cited
1996
Highly Cited
1996
Increased cyclic AMP-phosphodiesterase activity in peripheral blood leukocytes is associated with the immune and inflammatory… Expand
Highly Cited
1992
Highly Cited
1992
  • K. Mackie, B. Hille
  • Proceedings of the National Academy of Sciences…
  • 1992
  • Corpus ID: 25518023
The psychoactive properties of Cannabis sativa and its major biologically active constituent, delta 9-tetrahydrocannabinol, have… Expand
  • figure 1
  • figure 3
  • figure 2
  • figure 4
Highly Cited
1991
Highly Cited
1991
BACKGROUND Milrinone, a phosphodiesterase inhibitor, enhances cardiac contractility by increasing intracellular levels of cyclic… Expand