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Biochemistry of lipids, lipoproteins, and membranes
1. Physical Properties and Functional Roles of Lipids in Membranes (Pieter R. Cullis and Michael J. Hope). 2. Lipid Metabolism in Procaryotes (Suzanne Jackowski, John E. Cronan, Jr. and Charles O.… Expand
Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase.
Lipid droplets (LDs) are cellular storage organelles for neutral lipids that vary in size and abundance according to cellular needs. Physiological conditions that promote lipid storage rapidly and… Expand
A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans
Sterol regulatory element-binding proteins (SREBPs) activate genes involved in the synthesis and trafficking of cholesterol and other lipids and are critical for maintaining lipid homeostasis.… Expand
Phosphatidylcholine and choline homeostasis.
Phosphatidylcholine (PC) is made in mammalian cells from choline via the CDP-choline pathway. Animals obtain choline primarily from the diet or from the conversion of phosphatidylethanolamine (PE) to… Expand
Phosphatidylcholine biosynthesis and lipoprotein metabolism.
Phosphatidylcholine (PC) is the major phospholipid component of all plasma lipoprotein classes. PC is the only phospholipid which is currently known to be required for lipoprotein assembly and… Expand
Phospholipid biosynthesis in mammalian cells.
Identification of the genes and gene products involved in the biosynthesis of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine has lagged behind that in many other fields because… Expand
Is it time to reevaluate methyl balance in humans?
- L. M. Stead, J. Brosnan, M. Brosnan, D. Vance, R. Jacobs
- Biology, Medicine
- The American journal of clinical nutrition
S-Adenosylmethionine (AdoMet) is the major biological methyl donor. AdoMet's methyl group arises both from the diet (eg, methionine, choline, and betaine) and from de novo synthesis by the process of… Expand
The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis.
Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in mammalian membranes. In liver, PC is synthesized via the choline pathway or by methylation of PE via… Expand
Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity
OBJECTIVE—The etiology of type 2 diabetes often involves diet-induced obesity (DIO), which is associated with elevated plasma fatty acids and lipoprotein associated triglycerides. Since aberrant… Expand
The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes.
Hepatocytes obtained from rats fed a choline-deficient diet for 3 days were cultured in a medium +/- choline (100 microM) or methionine (200 microM). We investigated how choline deficiency affected… Expand