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Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes.
TLDR
In conclusion, AC2993 acutely and markedly reduces fasting and postprandial glucose concentrations in patients with type 2 diabetes.
Long‐term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over‐weight metformin‐treated patients with type 2 diabetes mellitus
Aim:  The ability of the incretin mimetic exenatide to improve glycaemic control and reduce body weight was assessed over 82 weeks in patients with type 2 diabetes failing to achieve glycaemic
Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes.
TLDR
AC2993 had significant effects on HbA(1c) levels in patients not currently achieving optimal glucose control with diet and/or OAAs, confirming AC2993 effects on fasting and postprandial glycemia.
Chemical and biological characterization of the inhibin family of protein hormones.
Publisher Summary This chapter discusses the chemical and biological characterization of the inhibin family of protein hormones, which is a family of peptides isolated from the follicular fluid or
Follistatin gene expression in the ovary and extragonadal tissues.
TLDR
The broad tissue distribution of follistsatin mRNA strongly suggests other physiological roles for follistatin besides the inhibition of pituitary FSH release and highly homologous to porcine and human follistatins.
Tomato alcohol dehydrogenase: purification and substrate specificity.
TLDR
The tomato enzyme differs from other reported plant enzymes in showing substantial activity on geraniol, and is inhibited slowly by iodoacetamide, and reversibly by acetamide and zinc-chelating compounds.
Metformin-associated lactic acidosis: Current perspectives on causes and risk.
TLDR
This literature-based review provides an update on the impact of renal function and other conditions on metformin plasma levels and the risk of MALA in patients with type 2 diabetes.
Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
TLDR
There was insufficient evidence to support a difference in risk of recurrent ischaemic stroke between rivaroxaban and aspirin among patients with known PFO, and dedicated trials of anticoagulation versus antiplatelet therapy or PFO closure, or both, are warranted.
Hormonal regulation of granulosa cell inhibin biosynthesis.
TLDR
Granulosa cell inhibin secretion is regulated by FSH and LH but not by PRL, presumably via a cAMP-mediated pathway, consistent with in vivo studies which showed that whereas FSH treatment for 2 days doubled serum inhibin levels when compared with basal levels, there was no increase in the concentration of extractable inhibin in ovarian tissue.
Insulin-like growth factor-binding protein (IGF-BP) inhibition of granulosa cell function: effect on cyclic adenosine 3',5'-monophosphate, deoxyribonucleic acid synthesis, and comparison with the
TLDR
The data suggest that IGF-BPs have a multifaceted mode of action on granulosa cell function, and may therefore be an important regulator of follicular growth and differentiation.
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