1-Methyl-3-isobutylxanthine

Known as: 3-Isobutyl-1-methylxanthine, 1-Methyl-3-isobutylxanthine [Chemical/Ingredient], 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)- 
A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with anti-apoptotic effects on the pancreatic beta cell… (More)
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Highly Cited
2002
Highly Cited
2002
Explant cultures of adult human trabecular bone fragments give rise to osteoblastic cells, that are known to express osteoblast… (More)
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Highly Cited
1998
Highly Cited
1998
IL-17 is a newly described, T cell-derived cytokine with ill-defined physiologic properties. As such, we examined the release of… (More)
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Highly Cited
1995
Highly Cited
1995
A G protein-coupled receptor for the pineal hormone melatonin was recently cloned from mammals and designated the Mel1a melatonin… (More)
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Highly Cited
1993
Highly Cited
1993
Mitogen-activated protein (MAP) kinases p42mapk and p44mapk are activated in cells stimulated with epidermal growth factor (EGF… (More)
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Highly Cited
1993
Highly Cited
1993
The effect of shear stress on the release of endothelin-1 (ET-1) from endothelial cells is at present controversial with various… (More)
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Highly Cited
1992
Highly Cited
1992
New insulin-secreting cell lines (INS-1 and INS-2) were established from cells isolated from an x-ray-induced rat transplantable… (More)
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Highly Cited
1991
Highly Cited
1991
A defined cultivation system was developed for the differentiation of pluripotent embryonic stem cells of the mouse into… (More)
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Highly Cited
1990
Highly Cited
1990
Islet amyloid polypeptide (IAPP) has been identified as the major constituent of the pancreatic amyloid of non-insulin-dependent… (More)
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Highly Cited
1987
Highly Cited
1987
1. The actions of serotonin (5-HT) on pyramidal cells of the CA1 region of the rat hippocampus were characterized using… (More)
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