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1-Methyl-3-isobutylxanthine

Known as: 3-Isobutyl-1-methylxanthine, 1-Methyl-3-isobutylxanthine [Chemical/Ingredient], 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)- 
A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby… 
National Institutes of Health

Related topics

Related topics

10 relations

Narrower (2)

1-isoamyl-3-isobutylxanthineisbufylline
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Broader (1)

Phosphodiesterase Inhibitors

Papers overview

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Highly Cited
1986
Highly Cited
1986
An inhibitory role for polyamines in protein kinase C activation and insulin secretion in mouse pancreatic islets.
The occurrence and function of polyamines in protein kinase C activation and insulin secretion in mouse pancreatic islets were… 
1986
1986
The use of a new dextran gradient medium for rapid isolation of functionally intact neonatal rat pancreatic islets.
The use of a new density gradient medium, Dextran M 70, is described for isolation of islets of Langerhans from collagenase… 
1983
1983
Regulation of adenylate cyclase activity by follicle-stimulating hormone and a gonadotropin-releasing hormone agonist in cultured rat granulosa cells.
The effects of FSH and a GnRH agonist on adenylate cyclase activity and FSH receptor content were studied in granulosa cells… 
1983
1983
Glucose Stimulation of Beta-Cell DNA Replication in the Intact Rat and in Pancreatic Islets in Suspension Culture: Effects of Alpha-Ketoisocaproic Acid, Dibutyryl Cyclic AMP, and 3-Isobutyl-1…
DNA replication in pancreatic beta-cells was compared in intact rats maintained hyperglycemie by continuous glucose infusion up… 
1982
1982
Effects of adenosine, 2-deoxyadenosine and N6-phenylisopropyladenosine on rat islet function and metabolism.
Adenosine (1.0-100 mum). N(6)-phenylisopropyladenosine (0.1-10 mum) and 2-deoxyadenosine (10 mm) all produced a dose-dependent… 
Highly Cited
1981
Highly Cited
1981
Mobilization of a common source of smooth muscle Ca2+ by norepinephrine and methylxanthines.
The ability of norepinephrine (NE), caffeine (CAF), theophylline (THEO), dinitrophenol (DNP), and potassium (high K) to mobilize… 
1979
1979
Modulation of cellular interactions between C3H/10T1/2 cells and their transformed counterparts by phosphodiesterase inhibitors.
It has been demonstrated previously that nontransformed C3H/10T1/2CL8 mouse embryo fibroblasts (10T1/2) can induce a state of… 
Highly Cited
1977
Highly Cited
1977
Perfusion of the pancreas isolated from pertussis-sensitized rats: potentiation of insulin secretory responses due to beta-adrenergic stimulation.
In order to study the mechanism by which pertussis-sensitized rats showed enhanced insulin secretory responses to various… 
Highly Cited
1976
Highly Cited
1976
Insulin release and cyclic AMP accumulation in response to glucose in pancreatic islets of fed and starved rats.
The dose as well as the time kinetics of insulin and adenosine-3', 5' -monophosphate (cyclic AMP) responses to glucose were… 
Highly Cited
1975
Highly Cited
1975
Decreased Cyclic AMP and Insulin Response to Glucose in Isolated Islets of Neonatal Rats
The (3H) cyclic AMP accumulation was measured in incubations of pancreatic islets from one-day, six-day, and thirty-five-day-old…