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1-Methyl-3-isobutylxanthine

Known as: 3-Isobutyl-1-methylxanthine, 1-Methyl-3-isobutylxanthine [Chemical/Ingredient], 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)- 
A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby… Expand
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
Explant cultures of adult human trabecular bone fragments give rise to osteoblastic cells, that are known to express osteoblast… Expand
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Highly Cited
1998
Highly Cited
1998
IL-17 is a newly described, T cell-derived cytokine with ill-defined physiologic properties. As such, we examined the release of… Expand
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Highly Cited
1998
Highly Cited
1998
The decrease in bone volume associated with osteoporosis and age-related osteopenia is accompanied by increased marrow adipose… Expand
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Highly Cited
1997
Highly Cited
1997
Mammalian sperm capacitation, defined as an obligatory maturational process leading to the development of the fertilization… Expand
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Highly Cited
1995
Highly Cited
1995
A G protein-coupled receptor for the pineal hormone melatonin was recently cloned from mammals and designated the Mel1a melatonin… Expand
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Highly Cited
1994
Highly Cited
1994
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] inhibited the aggregation of and ATP release from washed rabbit platelets… Expand
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Highly Cited
1993
Highly Cited
1993
Mitogen-activated protein (MAP) kinases p42mapk and p44mapk are activated in cells stimulated with epidermal growth factor (EGF… Expand
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Highly Cited
1993
Highly Cited
1993
We have shown previously that exposure of rat uterine cells in primary culture to estradiol (E2), insulin-like growth factor-I… Expand
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Highly Cited
1992
Highly Cited
1992
New insulin-secreting cell lines (INS-1 and INS-2) were established from cells isolated from an x-ray-induced rat transplantable… Expand
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Highly Cited
1991
Highly Cited
1991
A defined cultivation system was developed for the differentiation of pluripotent embryonic stem cells of the mouse into… Expand
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