Skip to search formSkip to main contentSkip to account menu

phosphoric diester hydrolase

Known as: PDE, Phosphoric Diester Hydrolases [Chemical/Ingredient], Phosphoric Diester Hydrolases 
A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.
National Institutes of Health

Related topics

Related topics

45 relations

Narrower (31)

(acyl-carrier-protein) phosphodiesterase1-Phosphatidylinositol phosphodiesterase2',3'-Cyclic-Nucleotide Phosphodiesterases3',5'-Cyclic-Nucleotide Phosphodiesterase
3',5'-cyclic-nucleotide phosphodiesterase activityIn BloodPDE6H genePDE7A gene

Broader (2)

EsterasesPhosphoric Monoester Hydrolases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.
Review
2006
Review
2006
Mechanisms of cyclic-di-GMP signaling in bacteria.
Cyclic-di-GMP is a ubiquitous second messenger in bacteria. The recent discovery that c-di-GMP antagonistically controls motility… 
Highly Cited
2005
Highly Cited
2005
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
Cyclic adenosine 3′, 5′-monophosphate (cAMP) is a ubiquitous mediator of intracellular signalling events. It acts principally… 
Highly Cited
2002
Highly Cited
2002
Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes
The second messenger cyclic adenosine monophosphate (cAMP) is the most important modulator of sympathetic control over cardiac… 
Review
2001
Review
2001
Cyclic nucleotide phosphodiesterases: relating structure and function.
Review
2000
Review
2000
Guanylyl cyclases and signaling by cyclic GMP.
Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP. The family comprises both membrane-bound… 
Review
1998
Review
1998
Mammalian RGS Proteins: Barbarians at the Gate*
Hundreds or thousands of chemical and physical stimuli regulate the functions of eukaryotic cells by controlling the activities… 
Review
1996
Review
1996
Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential.
Review
1993
Review
1993
Intracellular cyclic GMP receptor proteins
Cyclic GMP is recognized as an important intracellular mediator of extracellular signals such as nitric oxide and natriuretic… 
Review
1990
Review
1990
Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)