phosphoric diester hydrolase

Known as: PDE, Phosphoric Diester Hydrolases [Chemical/Ingredient], Phosphoric Diester Hydrolases 
A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1945-2018
020040060080019452017

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Highly Cited
2012
Highly Cited
2012
Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and… (More)
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Highly Cited
2006
Highly Cited
2006
Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, flies, and worms. Mammals have seven Sir2… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic guanosine monophosphate, thereby… (More)
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Highly Cited
2005
Highly Cited
2005
Sustained cardiac pressure overload induces hypertrophy and pathological remodeling, frequently leading to heart failure… (More)
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Highly Cited
2005
Highly Cited
2005
Biofilms are adherent aggregates of bacterial cells that form on biotic and abiotic surfaces, including human tissues. Biofilms… (More)
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Highly Cited
1996
Highly Cited
1996
The present study demonstrates that chronic, but not acute, adminstration of several different classes of antidepressants… (More)
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Highly Cited
1996
Highly Cited
1996
Sildenafil (Viagra, UK-92,480) is a novel oral agent under development for the treatment of penile erectile dysfunction. Erection… (More)
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Highly Cited
1991
Highly Cited
1991
BACKGROUND Milrinone, a phosphodiesterase inhibitor, enhances cardiac contractility by increasing intracellular levels of cyclic… (More)
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Highly Cited
1990
Highly Cited
1990
Aggregation of human washed platelets with collagen is accompanied by a concentration-dependent increase in cyclic GMP but not… (More)
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Highly Cited
1990
Highly Cited
1990
MICE homozygous for the rd mutation display hereditary retinal degeneration and the classic rd lines serve as a model for human… (More)
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