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phosphoric diester hydrolase

Known as: PDE, Phosphoric Diester Hydrolases [Chemical/Ingredient], Phosphoric Diester Hydrolases 
A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and… Expand
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Review
2010
Review
2010
To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO… Expand
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Review
2006
Review
2006
Cyclic nucleotide phosphodiesterases (PDEs), which are ubiquitously distributed in mammalian tissues, play a major role in cell… Expand
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Review
2004
Review
2004
More than 20% of the human genome encodes proteins involved in transmembrane and intracellular signaling pathways. The cAMP… Expand
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Review
2003
Review
2003
cAMP is a second messenger that controls many key cellular functions. The only way to inactivate cAMP is to degrade it through… Expand
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Highly Cited
2002
Highly Cited
2002
The second messenger cyclic adenosine monophosphate (cAMP) is the most important modulator of sympathetic control over cardiac… Expand
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Review
2000
Review
2000
The past eighteen months have provided much progress in the cyclic nucleotide phosphodiesterase (PDE) field. Six new… Expand
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Review
1996
Review
1996
1. More than 300 coumarins have been identified from natural sources, especially green plants. The pharmacological and… Expand
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Highly Cited
1996
Highly Cited
1996
Sildenafil (Viagra, UK-92,480) is a novel oral agent under development for the treatment of penile erectile dysfunction. Erection… Expand
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Review
1992
Review
1992
Caffeine is the most widely consumed central-nervous-system stimulant. Three main mechanisms of action of caffeine on the central… Expand
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