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cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic nucleotideExpand
Cyclic nucleotide phosphodiesterases: relating structure and function.
Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of metallophosphohydrolases that specifically cleave the 3',5'-cyclic phosphate moiety of cAMP and/or cGMP to produce theExpand
Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions.
The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11 families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of cellular cN levels and,Expand
Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings
Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE5), which has been shown to be a clinically effective treatment for erectile dysfunction. Its action results from increased levelsExpand
Structure and function of cyclic nucleotide-dependent protein kinases.
Cyclic AMP-dependent protein kinase (cAK) was first described in 19631964 (43, 132) as a cAMP-dependent glycogen synthase kinase that, in the presence of Mg/ A TP, transferred the 'V-phosphate of AExpand
Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action.
  • S. Francis, J. Corbin
  • Biology, Medicine
  • Critical reviews in clinical laboratory sciences
  • 1 August 1999
Intracellular cAMP and cGMP levels are increased in response to a variety of hormonal and chemical stimuli; these nucleotides play key roles as second messenger signals in modulating myriadExpand
Cyclic GMP Phosphodiesterase-5: Target of Sildenafil*
The advent of the medication, sildenafil, for treatment of male impotence has attracted widespread attention. This agent potently inhibits a cGMP-binding cGMP-specific phosphodiesterase (PDE5). PDE5Expand
Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries.
Elevation of either cAMP or cGMP causes smooth muscle relaxation. Whether these effects are mediated through cAMP-dependent protein kinase (cAK), cGMP-dependent protein kinase (cGK), or both isExpand
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase.
Cyclic nucleotide analogs were used to study relaxation of pig coronary arteries and guinea pig tracheal smooth muscle in an attempt to determine the roles of cAMP- and cGMP-dependent protein kinasesExpand
Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities.
In addition to its cGMP-selective catalytic site, cGMP-binding cGMP-specific phosphodiesterase (PDE5) contains two allosteric cGMP-binding sites and at least one phosphorylation site (Ser92) on eachExpand