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Liquid domains in vesicles investigated by NMR and fluorescence microscopy.
We use (2)H-NMR, (1)H-MAS NMR, and fluorescence microscopy to detect immiscibility in three particular phospholipid ratios mixed with 30% cholesterol: 2:1 DOPC/DPPC, 1:1 DOPC/DPPC, and 1:2 DOPC/DPPC.Expand
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Membrane lateral compressibility determined by NMR and x-ray diffraction: effect of acyl chain polyunsaturation.
The elastic area compressibility modulus, Ka, of lamellar liquid crystalline bilayers was determined by a new experimental approach using 2H-NMR order parameters of lipid hydrocarbon chains togetherExpand
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Mechanisms of action of docosahexaenoic acid in the nervous system
AbtractThis review describes (from both the animal and human literature) the biological consequences of losses in nervous system docosahexaenoate (DHA). It then concentrates on biological mechanismsExpand
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Membrane dipole potentials, hydration forces, and the ordering of water at membrane surfaces.
We have compared hydration forces, electrical dipole potentials, and structural parameters of dispersions of dipalmitoylphosphatidylcholine (DPPC) and dihexadecylphosphatidylcholine (DHPC) toExpand
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Critical fluctuations in domain-forming lipid mixtures
Critical fluctuations are investigated in lipid membranes near miscibility critical points in bilayers composed of dioleoylphosphatidylcholine, chain perdeuterated dipalmitoylphosphatidylcholine, andExpand
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The preference of tryptophan for membrane interfaces.
One of the ubiquitous features of membrane proteins is the preference of tryptophan and tyrosine residues for membrane surfaces that presumably arises from enhanced stability due to distinctExpand
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Polyunsaturated docosahexaenoic vs docosapentaenoic acid-differences in lipid matrix properties from the loss of one double bond.
Insufficient supply to the developing brain of docosahexaenoic acid (22:6n3, DHA), or its omega-3 fatty acid precursors, results in replacement of DHA with docosapentaenoic acid (22:5n6, DPA), anExpand
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Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures.
We investigated lateral lipid organization in membranes with a lipid composition relevant to neural and retinal membranes [phosphatidylcholine (PC)/phosphatidylethanolamine (PE)/phosphatidylserineExpand
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Specific volumes of unsaturated phosphatidylcholines in the liquid crystalline lamellar phase.
The specific volumes of seven 1,2-diacyl-sn-glycero-3-phosphocholines with symmetric, unbranched acyl chains containing one, four, or six cis double bonds per chain, or with a saturated sn-1 chainExpand
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Progressive ordering with decreasing temperature of the phospholipids of influenza virus.
Using linewidth and spinning sideband intensities of lipid hydrocarbon chain resonances in proton magic angle spinning NMR spectra, we detected the temperature-dependent phase state of naturallyExpand
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