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droloxifene

Known as: (E)--1-[4'-(2-dimethylaminoethyoxy)phenyl]-1(3-hydroxyphenyl)-2-phenyl-but-1-ene, (E)-3-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol, 3-hydroxytamoxifen 
A phenolic analogue of tamoxifen, a nonsteroidal selective estrogen receptor modulator (SERM). Droloxifene competitively inhibits the binding of… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (4)

Antineoplastic AgentsAntioxidantsEstrogen AntagonistsTamoxifen

Narrower (2)

FK 435droloxifene citrate
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Effects of conjugated oestrogen and droloxifene on the renin–angiotensin system, blood pressure and renal blood flow in postmenopausal women
objective  The aim of this study was to evaluate the effect of conjugated equine oestrogen (CEE), and droloxifene, a selective… 
Review
2001
Review
2001
Effects of SERMs on important indicators of cardiovascular health: lipoproteins, hemostatic factors, and endothelial function.
2001
2001
DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives.
The non-steroidal anti-estrogen tamoxifen is used as an adjunct chemotherapeutic agent for the treatment of all stages of breast… 
1995
1995
Influence of treatment with the anti-oestrogen 3-hydroxytamoxifen (droloxifene) on plasma sex hormone levels in postmenopausal patients with breast cancer.
Plasma levels of oestradiol (Oe2), oestrone (Oe1) oestrone sulphate (Oe1S), androstenedione, testosterone, dehydroepiandrosterone… 
1992
1992
Droloxifene--a new anti-estrogen. A phase II study in advanced breast cancer.
Twenty-six patients with advanced breast cancer were treated with a new anti-estrogen, Droloxifene (3-hydroxy-tamoxifen). They… 
1991
1991
Japanese Early Phase II Study of Droloxifene in the Treatment of Advanced Breast Cancer Preliminary Dose‐Finding Study
Droloxifene, a new tamoxifen (TAM)-derived compound, has excellent antiestrogenic activity. This compound exhibits less… 
1991
1991
Antitumor effects of droloxifene, a new antiestrogen drug, against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats.
The antitumor effects of droloxifene (DROL, (E)-alpha-[p-[2-(dimethylamino)ethoxy]-phenyl]-alpha-ethyl-3-stilbeno l), a new… 
Highly Cited
1989
Highly Cited
1989
Oestrogenic activity of tamoxifen and its metabolites on gene regulation and cell proliferation in MCF-7 breast cancer cells.
The effects of tamoxifen, three of its in vivo metabolites and 3-hydroxytamoxifen on cellular proliferation and the induction of… 
1989
1989
Antiestrogenic and antitumor effects of droloxifene in experimental breast carcinoma.
The pharmacological effects of droloxifene [E)-a [p-[2-(dimethylamino)ethoxy]phenyl]-a'-ethyl-3-stilbenol, FK435), a new… 
Highly Cited
1985
Highly Cited
1985
In vivo and in vitro antiestrogenic action of 3-hydroxytamoxifen, tamoxifen and 4-hydroxytamoxifen.
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