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droloxifene

Known as: (E)--1-[4'-(2-dimethylaminoethyoxy)phenyl]-1(3-hydroxyphenyl)-2-phenyl-but-1-ene, (E)-3-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol, 3-hydroxytamoxifen 
A phenolic analogue of tamoxifen, a nonsteroidal selective estrogen receptor modulator (SERM). Droloxifene competitively inhibits the binding of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
A series of ferrocene derivatives based upon the structure of the antiestrogenic drug tamoxifen or of its active metabolite… Expand
Highly Cited
2002
Highly Cited
2002
1. Preliminary studies have identified cytochrome P450 (CYP) 3A4 and CYP1B1 as the human CYPs inhibited by tamoxifen. To quantify… Expand
Highly Cited
1999
Highly Cited
1999
We used mouse hepatoma (Hepa1c1c7) cells to study the role of the serine/threonine kinase Akt in the induction ofGLUT1 gene… Expand
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Highly Cited
1998
Highly Cited
1998
We have discovered a new, nonsteroidal, potent estrogen agonist/antagonist, CP-336,156. CP-336,156 binds selectively and with… Expand
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Highly Cited
1997
Highly Cited
1997
PURPOSE Overexpression of the HER-2/c-neu/c-erbB2 proto-oncogene is associated with a worse prognosis in patients with breast… Expand
1995
1995
The purpose of this study was to determine the efficacy of droloxifene (DRO), an estrogen antagonist/agonist, in preventing… Expand
Highly Cited
1995
Highly Cited
1995
The purpose of this study was to determine the effects of droloxifene (DRO), a new estrogen antagonist/agonist, on bone turnover… Expand
Highly Cited
1992
Highly Cited
1992
Chronic administration of tamoxifen to female rats causes hepatocellular carcinomas. We have investigated damage to liver DNA… Expand
Highly Cited
1989
Highly Cited
1989
The effects of tamoxifen, three of its in vivo metabolites and 3-hydroxytamoxifen on cellular proliferation and the induction of… Expand
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Highly Cited
1982
Highly Cited
1982
Abstract In the rat uterus, trans-tamoxifen (ICI-47,699, 1-[4-(2-dimethylaminoethoxy)phenyl]-1,2-diphenylbut-1(E)-ene) is a full… Expand
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