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droloxifene

Known as: (E)--1-[4'-(2-dimethylaminoethyoxy)phenyl]-1(3-hydroxyphenyl)-2-phenyl-but-1-ene, (E)-3-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol, 3-hydroxytamoxifen 
A phenolic analogue of tamoxifen, a nonsteroidal selective estrogen receptor modulator (SERM). Droloxifene competitively inhibits the binding of… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (4)

Antineoplastic AgentsAntioxidantsEstrogen AntagonistsTamoxifen

Narrower (2)

FK 435droloxifene citrate
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Comparison of the effects of EM‐652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW‐5638 and raloxifene on the growth of human ZR‐75‐1 breast tumors in nude mice
EM‐652 exerts pure antiestrogenic activity in the mammary gland and endometrium, while tamoxifen, the antiestrogen most widely… 
2001
2001
DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives.
The non-steroidal anti-estrogen tamoxifen is used as an adjunct chemotherapeutic agent for the treatment of all stages of breast… 
2001
2001
Effects of droloxifene on apoptosis and Bax, Bcl-2 protein expression of luteal cells in pseudopregnant rats.
AIM To study the effects of droloxifene on apoptosis and the expression of Bax and Bcl-2 protein in corpus luteum of… 
1995
1995
Influence of treatment with the anti-oestrogen 3-hydroxytamoxifen (droloxifene) on plasma sex hormone levels in postmenopausal patients with breast cancer.
Plasma levels of oestradiol (Oe2), oestrone (Oe1) oestrone sulphate (Oe1S), androstenedione, testosterone, dehydroepiandrosterone… 
1993
1993
The estrogenic and antiestrogenic activities of droloxifene in human breast cancers.
The effects of a new antiestrogen, droloxifene (DROL, (E)-alpha-[p-[2-(dimethylamino)ethoxy]-phenyl]-alpha'-ethyl-3- stilbenol… 
1991
1991
Japanese Early Phase II Study of Droloxifene in the Treatment of Advanced Breast Cancer Preliminary Dose‐Finding Study
Droloxifene, a new tamoxifen (TAM)-derived compound, has excellent antiestrogenic activity. This compound exhibits less… 
1991
1991
Antitumor effects of droloxifene, a new antiestrogen drug, against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats.
The antitumor effects of droloxifene (DROL, (E)-alpha-[p-[2-(dimethylamino)ethoxy]-phenyl]-alpha-ethyl-3-stilbeno l), a new… 
1991
1991
European Early Phase II Dose‐Finding Study of Droloxifene in Advanced Breast Cancer
Preliminary results from clinical phase II studies with droloxifene demonstrated efficacy and good tolerability. One hundred… 
1989
1989
Antiestrogenic and antitumor effects of droloxifene in experimental breast carcinoma.
The pharmacological effects of droloxifene [E)-a [p-[2-(dimethylamino)ethoxy]phenyl]-a'-ethyl-3-stilbenol, FK435), a new… 
Highly Cited
1985
Highly Cited
1985
In vivo and in vitro antiestrogenic action of 3-hydroxytamoxifen, tamoxifen and 4-hydroxytamoxifen.
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