FAQ

Estrogen Antagonists

Known as: Antiestrogens, estrogen blocker, Estrogen--Antagonists 
A substance that keeps cells from making or using estrogen (a hormone that plays a role in female sex characteristics, the menstrual cycle, and… (More)

Topic mentions per year

Topic mentions per year

1951-2018
05010015019512017

Related topics

Related topics

41 relations
AndrogensAntineoplastic AgentsAromatase InhibitorsEstrogen Receptor Modulators
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Narrower (26)

CentchromanClomipheneDanazolEM 800
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Broader (2)

Hormone AntagonistsPharmaceutical Preparations

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Estrogen Antagonists
Steroids
Estrogens
Clomiphene
Androgens
Tamoxifen

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer.
PURPOSE Cross-talk between human epidermal growth factor receptors and hormone receptor pathways may cause endocrine resistance… (More)
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Highly Cited
2002
Highly Cited
2002
Molecular determinants for the tissue specificity of SERMs.
Selective estrogen receptor modulators (SERMs) mimic estrogen action in certain tissues while opposing it in others. The… (More)
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Highly Cited
2001
Highly Cited
2001
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.
Estrogen receptors (ERs) mediate most of the biological effects of estrogen in mammary and uterine epithelial cells by binding to… (More)
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Highly Cited
2001
Highly Cited
2001
Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.
Trans-3,4',5-trihydroxystilbene (resveratrol), a phytoalexin present in grapes and grape products such as wine, has been… (More)
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Highly Cited
1998
Highly Cited
1998
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
The rat, mouse and human estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal… (More)
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Highly Cited
1997
Highly Cited
1997
Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen.
Mixed antiestrogens, such as 4-hydroxytamoxifen (4HT), act as either partial agonists or antagonists of estrogen receptor (ER… (More)
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Highly Cited
1995
Highly Cited
1995
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase.
The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER… (More)
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Highly Cited
1995
Highly Cited
1995
Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.
We have developed a series of in vitro models with which to evaluate the biological activity of estrogen receptor (ER) agonists… (More)
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Highly Cited
1992
Highly Cited
1992
Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer.
BACKGROUND AND METHODS Tamoxifen, a synthetic antiestrogen, increases disease-free and overall survival when used as adjuvant… (More)
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Highly Cited
1978
Highly Cited
1978
Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen.
Estrogen antagonists are widely used in the treatment of breast cancer, and studies of their mechanism of action may provide… (More)
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