Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells.

@article{Komi2000NonsteroidalAI,
  title={Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells.},
  author={Janne O Komi and Olli Lassila},
  journal={Blood},
  year={2000},
  volume={95 9},
  pages={2875-82}
}
Dendritic cells (DC) are professional antigen-presenting cells with a unique capacity to initiate and regulate immune responses. Immature CD1a(+) DC can be cultured from CD14(+) monocytes in the presence of interleukin (IL)-4 and granulocyte macrophage colony-stimulating factor in vitro. Results of this study show that the nonsteroidal anti-estrogens toremifene and tamoxifen inhibit this differentiation. In the presence of anti-estrogens the cells lose CD14 expression, but remain CD1a(-) and… CONTINUE READING

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Tamoxifen inhibits acidification in cells independent of the estrogen receptor.

Proceedings of the National Academy of Sciences of the United States of America • 1999

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