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Aromatase Inhibitors

Known as: Androstenedione Aromatase Inhibitor, Estrogen Synthase Inhibitor, Estrogen Synthetase Inhibitor 
Any substance that inhibits aromatase, an enzyme responsible for the conversion of cholesterol to pregnenolone and the peripheral aromatization of… 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (9)

AminoglutethimideFadrozoleanastrozoleexemestane

Broader (1)

Enzyme Inhibitors
Estrogen AntagonistsIn Bloodaspects of radiation effectschemical synthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Aromatase inhibitor-induced arthralgia: a review.
Though aromatase inhibitors (AIs) are an essential part of estrogen receptor-positive (ER+) breast cancer therapy, many patients… 
Highly Cited
2009
Highly Cited
2009
Successful fertility treatment for Klinefelter's syndrome.
Review
2007
Review
2007
Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women.
BACKGROUND Hormonal treatments for advanced or metastatic breast cancer, such as tamoxifen and the progestins megestrol acetate… 
Review
2007
Review
2007
The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer
The third‐generation aromatase inhibitors (AIs) anastrozole, exemestane and letrozole have largely replaced tamoxifen as the… 
Review
2007
Review
2007
Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development.
Highly Cited
2006
Highly Cited
2006
Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis.
BACKGROUND Aromatase inhibitors and inactivators have been extensively tested in patients with advanced breast cancer, but it is… 
Review
2006
Review
2006
Aromatase and other steroidogenic genes in endometriosis: translational aspects.
Endometriosis is a common, chronic and estrogen-dependent gynaecological disorder associated with pelvic pain and infertility. In… 
Highly Cited
2005
Highly Cited
2005
Aromatase inhibitors in human lung cancer therapy.
Lung cancer is the most common cancer in the world. It is a highly lethal disease in women and men, and new treatments are… 
Review
2001
Review
2001
Aromatase, Aromatase Inhibitors, and Breast Cancer
Estrogens are involved in numerous physiologic processes and have crucial roles in particular disease states, such as mammary… 
Highly Cited
1997
Highly Cited
1997
Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium.
To determine whether local estrogen production takes place in endometriotic or adenomyotic tissues, in eutopic endometrium from… 
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