Aromatase Inhibitors

Known as: Androstenedione Aromatase Inhibitor, Estrogen Synthase Inhibitor, Estrogen Synthetase Inhibitor 
Any substance that inhibits aromatase, an enzyme responsible for the conversion of cholesterol to pregnenolone and the peripheral aromatization of… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Resistance to endocrine therapy in breast cancer is associated with activation of the mammalian target of rapamycin… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE Cross-talk between signal transduction pathways likely contributes to hormone resistance in metastatic breast cancer (mBC… (More)
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Highly Cited
2011
Highly Cited
2011
Elevated circulating estrogen levels are associated with increased risk of breast cancer in obese postmenopausal women. Following… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE To conduct meta-analyses of randomized trials of aromatase inhibitors (AIs) compared with tamoxifen either as initial… (More)
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Review
2009
Review
2009
Endocrine therapies targeting oestrogen action (anti-oestrogens, such as tamoxifen, and aromatase inhibitors) decrease mortality… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Adjuvant aromatase inhibitor therapy is well established in postmenopausal women with hormone receptor-positive breast… (More)
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Review
2005
Review
2005
PURPOSE To update the 2003 American Society of Clinical Oncology technology assessment on adjuvant use of aromatase inhibitors… (More)
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Highly Cited
2005
Highly Cited
2005
Lung cancer is the most common cancer in the world. It is a highly lethal disease in women and men, and new treatments are… (More)
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Review
2003
Review
2003
Endocrine therapy with tamoxifen has been the mainstay of treatment for hormone-sensitive breast cancer for more than 20 years… (More)
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Highly Cited
2003
Highly Cited
2003
Aromatase inhibitors have recently been reported to be more effective than the antiestrogen tamoxifen (Tam) in treating breast… (More)
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