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Aromatase Inhibitors

Known as: Androstenedione Aromatase Inhibitor, Estrogen Synthase Inhibitor, Estrogen Synthetase Inhibitor 
Any substance that inhibits aromatase, an enzyme responsible for the conversion of cholesterol to pregnenolone and the peripheral aromatization of… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
PURPOSE To update the ASCO clinical practice guideline on adjuvant endocrine therapy based on emerging data about the optimal… Expand
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Review
2018
Review
2018
BACKGROUND Polycystic ovary syndrome (PCOS) is the most common cause of infrequent periods (oligomenorrhoea) and absence of… Expand
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Review
2016
Review
2016
Importance Estrogen receptor-positive (ER+) tumors of the breast are generally highly responsive to endocrine treatment. Although… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND The optimal ways of using aromatase inhibitors or tamoxifen as endocrine treatment for early breast cancer remains… Expand
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Highly Cited
2012
Highly Cited
2012
PURPOSE Cross-talk between signal transduction pathways likely contributes to hormone resistance in metastatic breast cancer (mBC… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Resistance to endocrine therapy in breast cancer is associated with activation of the mammalian target of rapamycin… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE To conduct meta-analyses of randomized trials of aromatase inhibitors (AIs) compared with tamoxifen either as initial… Expand
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Highly Cited
2008
Highly Cited
2008
  • G. Ellis, H. Bone, +5 authors S. Jun
  • Journal of clinical oncology : official journal…
  • 2008
  • Corpus ID: 545385
PURPOSE Adjuvant aromatase inhibitor therapy is well established in postmenopausal women with hormone receptor-positive breast… Expand
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Review
2005
Review
2005
PURPOSE To update the 2003 American Society of Clinical Oncology technology assessment on adjuvant use of aromatase inhibitors… Expand
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Review
2003
Review
2003
Endocrine therapy with tamoxifen has been the mainstay of treatment for hormone-sensitive breast cancer for more than 20 years… Expand
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