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Aminoglutethimide

Known as: 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione, AG, Dl-Aminoglutethimide 
A synthetic derivative of the sedative and anticonvulsant glutethimide with anti-steroid properties. Originally used as an anticonvulsant… 
National Institutes of Health

Related topics

Related topics

28 relations

Narrower (8)

4-methylaminoglutethimideCytadrenEliptenHPMA copolymer-Dox-AGM

Broader (6)

Antineoplastic AgentsAntineoplastic Agents, HormonalAromatase InhibitorsSympathomimetics
Cushing SyndromeDrug AllergyIn BloodMammary Neoplasms

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Activation-Induced Nonresponsiveness: A Th-Dependent Regulatory Checkpoint in the CTL Response1
CD8 T cells undergo autocrine IL-2-dependent proliferation upon TCR engagement and costimulation, but within 3–4 days, they… 
Highly Cited
1992
Highly Cited
1992
Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-gamma-producing (Th1) cells.
As a model for understanding in vivo immune responses, we have exposed mice to aqueous haptenated-protein Ag, and examined immune… 
Highly Cited
1991
Highly Cited
1991
Toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea in human cell lines with different DNA repair phenotypes.
We examined the toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea (ENU) in three Epstein-Barr virus… 
Highly Cited
1991
Highly Cited
1991
2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits steroidogenesis in the rat testis by inhibiting the mobilization of cholesterol to cytochrome P450scc.
Highly Cited
1989
Highly Cited
1989
Thyrotropin: an endogenous regulator of the in vitro immune response.
We have previously shown that thyrotropin (TSH), which is produced by lymphocytes in response to the T cell mitogen… 
Highly Cited
1988
Highly Cited
1988
Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation.
We have produced a hamster mAb, H1.2F3, which was derived by immunization with a murine TCR-gamma delta + epidermal T cell line… 
Highly Cited
1987
Highly Cited
1987
Testosterone inhibits cAMP-induced de Novo synthesis of Leydig cell cytochrome P-450(17 alpha) by an androgen receptor-mediated mechanism.
Highly Cited
1978
Highly Cited
1978
Mechanisms of corticotropin action in rat adrenal cells. I. The effects of inhibitors of protein synthesis and of microfilament formation on corticosterone synthesis.
Highly Cited
1977
Highly Cited
1977
Inhibition of testosterone-induced sexual behavior in the castrated male rat by aromatase blockers
Highly Cited
1975
Highly Cited
1975
Treatment of an adrenal cortical carcinoma with a combination of o,p′-DDD and aminoglutethimide
A patient with Cushing's syndrome due to an adrenocortical carcinoma is described. Treatment of residual disease and functional… 
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