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Fadrozole

Known as: Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo(1,5-a)pyridin-5-yl)-, Fadrozole [Chemical/Ingredient] 
A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (4)

AfemaCGS 020286ACGS-16949AFAD 286

Broader (3)

Antineoplastic Agents, HormonalAromatase InhibitorsEstrogen Antagonists
Fadrozole HydrochlorideIn Bloodagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Molecular Docking of Aromatase Inhibitors
Aromatase is an enzyme that plays a critical role in the development of estrogen receptor positive breast cancer. As aromatase… 
Highly Cited
2006
Highly Cited
2006
Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production.
Highly Cited
2006
Highly Cited
2006
Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS/MS method for the analysis of estradiol product formation.
Review
2005
Review
2005
Gonadal histology and characteristic histopathology associated with endocrine disruption in the adult fathead minnow (Pimephales promelas).
Review
2005
Review
2005
Aromatase Inhibition: Translation into a Successful Therapeutic Approach
The development of the novel third-generation aromatase inhibitors and inactivators for breast cancer treatment is one of the… 
Highly Cited
2004
Highly Cited
2004
Aromatase modulation alters gonadal differentiation in developing zebrafish (Danio rerio).
Highly Cited
2002
Highly Cited
2002
Evaluation of the aromatase inhibitor fadrozole in a short-term reproduction assay with the fathead minnow (Pimephales promelas).
Cytochrome P450 aromatase (CYP19) is a key enzyme in vertebrate steroidogenesis, catalyzing the conversion of C19 androgens to… 
Highly Cited
2002
Highly Cited
2002
Elevated serum Her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer.
PURPOSE To determine the effect of elevation of serum HER-2/neu on response to hormone therapy. PATIENTS AND METHODS Seven… 
Highly Cited
2002
Highly Cited
2002
Effects of the aromatase inhibitor letrozole on normal breast epithelial cell proliferation and metabolic indices in postmenopausal women: a pilot study for breast cancer prevention.
The aromatase enzyme converts androgens to estrogens and is the therapeutic target for aromatase inhibitors in postmenopausal… 
Review
2000
Review
2000
CYP2A6: a human coumarin 7-hydroxylase.
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