Skip to search formSkip to main contentSkip to account menu

Fadrozole Hydrochloride

Known as: Monohydrochloride, Fadrozole, Hydrochloride, Fadrozole, 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Monohydrochloride 
The hydrochloride salt of the nonsteroidal aromatase inhibitor fadrozole with potential antineoplastic activity. Fadrozole specifically inhibits… 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

Afema
CGS-16949A

Broader (1)

Fadrozole

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Effects of Fadrozole (CGS 16949A) and Letrozole (CGS 20267) on the inhibition of aromatase activity in breast cancer patients
SummaryFadrozole Hydrochloride (CGS 16949A) and Letrozole (CGS 20267), are two of the newest non-steroidal, orally active… 
Highly Cited
1999
Highly Cited
1999
Effects of the aromatase inhibitor Fadrozole on plasma sex steroid secretion and ovulation rate in female coho salmon, Oncorhynchus kisutch, close to final maturation.
Plasma levels of 17beta-estradiol, 17alpha, 20beta-dihydroxy-4-pregnen-3-one (17alpha,20beta-P), and testosterone were measured… 
1999
1999
Effect of the potent aromatase inhibitor fadrozole hydrochloride (CGS 16949A) in postmenopausal women with breast carcinoma
Fadrozole hydrochloride (CGS 16949A) is a highly potent, nonsteroidal aromatase inhibitor that significantly lowers estrogen… 
Highly Cited
1995
Highly Cited
1995
4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis.
Estradiol is converted to catechol estrogens via 2- and 4-hydroxylation by cytochrome P450 enzymes. 4-Hydroxyestradiol elicits… 
Highly Cited
1995
Highly Cited
1995
Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor.
Mammary tumours are oestrogen dependent in female Sprague-Dawley rats and in a significant proportion of women, so… 
Highly Cited
1994
Highly Cited
1994
Fadrozole: a potent and specific inhibitor of aromatase in the zebra finch brain.
Aromatase and 5 beta-reductase activity are expressed at high levels in the zebra finch brain, especially in the telencephalon… 
Highly Cited
1993
Highly Cited
1993
Effect of androstenedione on growth of untransfected and aromatase-transfected MCF-7 cells in culture
1993
1993
Separation of the enantiomers of some racemic nonsteroidal aromatase inhibitors and barbiturates by capillary electrophoresis.
High-performance capillary electrophoresis (HPCE) and micellar electrokinetic capillary chromatography (MECC) were applied to the… 
1993
1993
Structure-activity relationships and binding model of novel aromatase inhibitors
1992
1992
The effects of fadrozole hydrochloride on aldosterone secretion in healthy male subjects.
The aim of this double blind placebo-controlled cross-over study was to evaluate the effects of fadrozole, a new oral… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)