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Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor.

• Chunmei Yang, Dujin Zhou, Shiuan Chen
• Cancer research
• 1998

We have previously identified a silencer element (S1) that is situated between promoters I.3 and II of the human aromatase gene and that down-regulates the action of these promoters. We recently… (More)

MicroRNAs play a role in the development of human hematopoietic stem cells.

• Rongxia Liao, J Sun, +5 authors Shaoxiang Zhang
• Journal of cellular biochemistry
• 2008

MicroRNAs (miRNAs) are a class of recently discovered noncoding RNA genes that post-transcriptionally regulate gene expression. It is becoming clear that miRNAs play an important role in the… (More)

Autocrine and paracrine actions of breast tumor aromatase. A three-dimensional cell culture study involving aromatase transfected MCF-7 and T-47D cells.

• Xuemin Sun, Dujin Zhou, Shiuan Chen
• The Journal of steroid biochemistry and molecular…
• 1997

Stable aromatase-expressing MCF-7 and T-47D cell lines (i.e. MCF-7aro and T-47Daro) have been prepared by aromatase cDNA transfection and G418 (neomycin) selection. MCF-7aro was further subjected to… (More)

Binding characteristics of seven inhibitors of human aromatase: a site-directed mutagenesis study.

• Yu ‐ Chun Kao, Lucien Le Cam, Charles A. Laughton, Dujin Zhou, Shiuan W Chen
• Cancer research
• 1996

Aromatase, a cytochrome P450, catalyzes three consecutive hydroxylation reactions converting C19 androgens to aromatic C18 estrogenic steroids. In this study, eight human aromatase mutants (I133Y,… (More)

Breast tumor aromatase: functional role and transcriptional regulation.

• Shiuan Chen, Dujin Zhou, Tomoharu Okubo, Yeh Chih Kao, Chun Yang
• Endocrine-related cancer
• 1999

Aromatase has been shown to be expressed at a higher level in human breast cancer tissue than in normal breast tissue, by means of enzyme activity measurement, immunocytochemistry, and RT-PCR… (More)

Aromatase gene expression and its exon I usage in human breast tumors. Detection of aromatase messenger RNA by reverse transcription-polymerase chain reaction.

• Chuannong Zhou, Dujin Zhou, +4 authors Shiuan W Chen
• The Journal of steroid biochemistry and molecular…
• 1996

The expression of aromatase in human breast tumors has been studied by the reverse-transcription polymerase chain reaction (RT-PCR) method on 70 breast tissue specimens. An RT-PCR analysis using two… (More)

The pathogenesis of gonococcal urethritis in men: confocal and immunoelectron microscopic analysis of urethral exudates from men infected with Neisseria gonorrhoeae.

• Michael A. Apicella, Markus Ketterer, Francis Kwokshun Lee, Dujin Zhou, Peter A. Rice, Milan S. Blake
• The Journal of infectious diseases
• 1996

Confocal and immunoelectron microscopic analysis of urethral exudates from 12 men with gonococcal urethritis showed that Neisseria gonorrhoeae can invade urethral epithelial cells. Studies with… (More)

PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and…

• Dujin Zhou, Keith M Quach, Caimei Yang, Sun Yong Lee, Bill Pohajdak, Shao-yong Chen
• Molecular endocrinology
• 2000

PNRC (proline-rich nuclear receptor coregulatory protein) was identified using bovine SF1 (steroidogenic factor 1) as the bait in a yeast two-hybrid screening of a human mammary gland cDNA expression… (More)

A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC–Grb2 interaction

• Dujin Zhou, Bingguang Chen, Jing-jing Ye, Shiuan W Chen
• Oncogene
• 2004

It has been demonstrated that proline-rich nuclear receptor coregulatory protein (PNRC) is a nuclear receptor coactivator that interacts with nuclear receptors through an SH3-binding motif located in… (More)

Characterization of a silencer element in the human aromatase gene.

• Dujin Zhou, Shiuan Chen
• Archives of biochemistry and biophysics
• 1998

Aromatase, a cytochrome P450, catalyzes three consecutive hydroxylation reactions converting C19 androgens to aromatic C18 estrogens. The control of human aromatase expression is complex in that… (More)

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