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MicroRNAs play a role in the development of human hematopoietic stem cells
TLDR
Hsa‐miR‐520h transduction into CD34+ cells greatly increased number of different progenitor colonies in Colony‐Forming‐Cell assays, suggesting that hsa‐ MiRNAs may promote differentiation of HSCs into progenitors cells by inhibiting ABCG2 expression.
Molecular basis for the aromatization reaction and exemestane-mediated irreversible inhibition of human aromatase.
TLDR
Structural basis of the aromatization reaction and drug recognition by aromatase has remained elusive because of its unknown three-dimensional structure, and a new clamping mechanism of substrate/exemestane binding to the active site is proposed.
The molecular basis of the interaction between the proline-rich SH3-binding motif of PNRC and estrogen receptor alpha
TLDR
The results indicate that the PNRC–ERα interaction interface is not exactly identical to that of GRIP1–ERβ, a well-characterized coactivator.
Modulation of Aromatase Expression in the Breast Tissue by ERRα-1 Orphan Receptor
TLDR
The results suggest that ERR alpha-1 is one of the nuclear proteins interacting with S1 in breast cancer tissue, and it is thought that the silencer element in the human aromatase gene may function differently in different tissues because of distinct expression patterns of transcription factors.
Characterization of the weak estrogen receptor α agonistic activity of exemestane
TLDR
The steroidal AI, exemestane (EXE) has previously been shown to act as an androgen, but this report demonstrates the estrogen-like activity of EXE, suggesting that EXE does have weak estrogen- like activity.
A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC–Grb2 interaction
TLDR
It is believed that PNRC and Grb2, by interacting with each other, can suppress nuclear receptor- mediated regulation and growth factor-mediated regulation in human breast tissue.
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